ArticleAsian journal of andrology
Both comorbidity burden and low testosterone can explain symptoms and signs of testosterone deficiency in men consulting for sexual dysfunction.
Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Metabolic syndrome and erectile dysfunction: a systematic review and meta-analysis study.Journal of endocrinological investigation · 2023Pooled it
- Testosterone replacement therapy and spermatogenesis in reproductive age men.Nature reviews. Urology · 2025Review
- Sarcopenic obesity and reduced BMD in young men living with HIV: body composition and sex steroids interplay.Journal of endocrinological investigation · 2024Observational
- Are they functional hypogonadal men? Testosterone serum levels unravel male idiopathic infertility subgroups.Endocrine · 2024Article
- The role of male hypogonadism, aging, and chronic diseases in characterizing adult and elderly men with erectile dysfunction: a cross-sectional study.Basic and clinical andrology · 2023Article
- A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study.Frontiers in endocrinology · 2023Article
- Update on acquired hypogonadism in men living with HIV: pathogenesis, clinic, and treatment.Frontiers in endocrinology · 2023Review
- The role of testosterone in male sexual function.Reviews in endocrine & metabolic disorders · 2022Review
- Testosterone replacement therapy in the era of telemedicine.International journal of impotence research · 2022Review
- The Role of Sex Hormones in the Disparity of COVID-19 Outcomes Based on Gender.The journal of sexual medicine · 2021Article
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3 authors at 3 institutions in 1 country.
Funding
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Abstract
Low testosterone (T) is frequent in men with chronic illnesses. The clinical features of T deficiency (TD) overlap with those of chronic diseases. The aim of this study is to evaluate the relative contribution of chronic disease score (CDS) and low T to the presence of TD symptoms. A consecutive series of 3862 men (aged 52.1 ± 13.1 years) consulting for sexual dysfunction were studied. Several clinical and biochemical parameters were collected, including the structured interview, ANDROTEST, for the assessment of TD symptoms. Penile color Doppler ultrasound (PCDU) was also performed. Based on the medications taken, the CDS was calculated. For a subset of 1687 men, information on mortality was collected (follow-up of 4.3 ± 2.6 years). Higher CDS was associated with lower free and total T (TT) as well as with higher ANDROTEST score. When introducing CDS and TT in multivariable models adjusted for age, severe erectile dysfunction and impaired morning erections were associated with both CDS (odds ratio and 95% confidence interaval, OR [95% CI] = 1.25 [1.13; 1.37] and 1.38 [1.29; 1.48], respectively) and low TT (OR [95% CI] = 1.11 [1.00; 1.23] and 1.13 [1.06; 1.21], respectively). Similar results were obtained for PCDU parameters. Hypoactive sexual desire was associated with low TT (OR [95% CI] = 1.21 [1.13; 1.30]), whereas it was inversely related with CDS (OR [95% CI] = 0.91 [0.84; 0.97]). When considering mortality for major cardiovascular events, TT <8 nmol l
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