Evidence map›Paper›PMID 31249259›Full record

ReviewMedical gas research

Ozone therapy: a potential therapeutic adjunct for improving female reproductive health.

Zaher Merhi, Bhavika Garg, Rajean Moseley-LaRue, Amber Ray Moseley, André Hugo Smith, John Zhang

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Medical gas research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07035522 (Evaluation of the Effects of Ozone Therapy on Endometriosis), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07035522 nanot yet recruitingnot on this map

Evaluation of the Effects of Ozone Therapy on Endometriosis

TypeinterventionalSponsorUniversidade Federal do ParanáRan2025 to 2025Enrolled40ConditionsEndometriosis, Ozone Therapy, ThermographyArmsOzone therapy
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Exploring the Potential of HCurrent pharmaceutical design · 2025
    Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Zaher MerhiDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx; New Hope Fertility Center, New York, NY, USA.
Bhavika GargNew Hope Fertility Center, New York, NY, USA.
Rajean Moseley-LaRueHocatt USA LLC, Weatherford, TX, USA.
Amber Ray MoseleyHocatt USA LLC, Weatherford, TX, USA.
André Hugo SmithHocatt USA LLC, Weatherford, TX, USA.
John ZhangNew Hope Fertility Center, New York, NY, USA.
Weatherford (United States) · USNew Hope Fertility Center · USAlbert Einstein College of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ozone is emerging as a new adjunct therapeutic agent for female infertility. We here present a review of the literature, to date, pertaining to the effect of ozone therapy on tubal, ovarian, endometrial, and vaginal factors that could potentially affect female fertility. It also presents data pertaining to the relationship of ozone therapy on pelvic adhesion formation. Most data were performed on animals and very few human studies existed in the literature. Results suggested that ozone therapy could have beneficial effect on tubal occlusion, could protect from endometritis and vaginitis, might protect ovaries from ischemia and oocyte loss and finally might lead to less formation of pelvic adhesions. There is a critical need for human studies pertaining to ozone therapy, especially using safe methods of administration, such as transdermally or intravaginally, on female fertility.

Indexed as

AnimalsAntioxidantsEndometritisFallopian Tube DiseasesFemaleHumansInfectionsInfertility, FemaleOzonePelvic Inflammatory DiseaseAntioxidantsOzoneadhesionsfallopian tubeinfertilityoocyteovaryozone therapyreproductionuterusvagina

Identifiers

PMID31249259
PMCPMC6607862
OpenAlexW2951692200

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.