Evidence map›Paper›PMID 31249159›Full record

ArticleEndoscopic ultrasound

Changes in tumor vascularity depicted by contrast-enhanced EUS as a predictor of prognosis and treatment efficacy in patients with unresectable pancreatic cancer (PEACE): A study protocol.

Adrian Sãftoiu, Manoop S Bhutani, Takao Itoi, Paolo G Arcidiacono, Erwan Bories, Irina M Cazacu, Alina Constantin, Emmanuel Coronel, Christoph F Dietrich, Dan G Duda and 16 more

Abstract read
In one paragraph

Article in Endoscopic ultrasound. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Advanced EUS Imaging Techniques.Digestive diseases and sciences · 2022
    Review
  6. Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway.World journal of gastrointestinal oncology · 2021
    Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Adrian SãftoiuResearch Center of Gastroenterology and Hepatology Craiova, University of Medicine and Pharmacy Craiova, Craiova, Romania.
Manoop S BhutaniDepartment of Gastroenterology, Hepatology and Nutrition, MD Anderson Cancer Center, Houston, Texas, USA.
Takao ItoiDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Paolo G ArcidiaconoPancreato-Biliary Endoscopy and Endosonography Division, San Raffaele Scientific Institute, Vita Salute San Raffaele University Milan, Milan, Italy.
Erwan BoriesEndoscopy Unit, Paoli Calmettes Institute, Marseille, France.
Irina M CazacuResearch Center of Gastroenterology and Hepatology Craiova, University of Medicine and Pharmacy Craiova, Craiova, Romania; Department of Gastroenterology, Hepatology and Nutrition, MD Anderson Cancer Center, Houston, Texas, USA, USA.
Alina ConstantinDepartment of Gastroenterology, Ponderas Academic Hospital, Bucharest, Romania.
Emmanuel CoronelDepartment of Gastroenterology, Hepatology and Nutrition, MD Anderson Cancer Center, Houston, Texas, USA.
Christoph F DietrichMedical Department, Caritas-Krankenhaus, Uhlandstr 7, D-97980 Bad Mergentheim, Germany.
Dan G DudaDepartment of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.
Julio Iglesias GarciaDepartment of Gastroenterology and Hepatology, University Hospital of Santiago de Compostella, Santiago, Spain.
Michael HockeDepartment of Gastroenterology, Helios Kliniken Meiningen, Meiningen, Germany.
Andre IgneeMedical Department, Caritas-Krankenhaus, Uhlandstr 7, D-97980 Bad Mergentheim, Germany.
Christian JenssenDepartment of Internal Medicine, Krankenhaus Maerkisch-Oderland, D-15344 Strausberg and Brandenburg Institute of Clinical Ultrasound at Medical University Brandenburg, Germany.
Mariana JingaDepartment of Gastroenterology, Central Clinical Emergency Military Hospital Dr. Carol Davila, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.
Christopher KhorDepartment of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.
Kofi W OppongHPB Unit, Freeman Hospital, Newcastle upon Tyne, London, UK.
Stephen PereiraUniversity College London Institute for Liver and Digestive Health, Royal Free Hospital Campus, London, UK.
Maria Chiara PetronePancreato-Biliary Endoscopy and Endosonography Division, San Raffaele Scientific Institute, Vita Salute San Raffaele University Milan, Milan, Italy.
Erwin SantoTel Aviv Souraski Medical Center, Invasive Endoscopy Unit, Gastroenterology Institute, Tel Aviv, Israel.
Andrada SeiceanRegional Institute of Gastroenterology and Hepatology, University of Medicine and Pharmacy "Iuliu Hațieganu," Cluj-Napoca, Romania.
Dong Wan SeoAsan Medical Center, Seoul, South Korea.
Sun SiyuEndoscopy Center, Liaoning Engineering Technology Research Center of Diagnosis and Treatment of Digestive Endoscopy, Shengjing Hospital of China Medical University, Shenyang, China.
Peter VilmannGastrointestinal Unit, Copenhagen University Hospital Herlev, Herlev, Denmark.
Irving WaxmanCenter for Endoscopic Research and Therapeutics, University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Paul YeatonCarilion Clinic Roanoke, Roanoke, USA.

Funding

Department of Health PB-PG-0712-28114Medical Research Council G0801588
6 · The paper itself

Abstract

Patients with unresectable pancreatic cancer have a poor prognosis. The analysis of prognostic factors before treatment may be helpful in determining the best therapeutic strategies. The aim of the PEACE study is to assess the vascularity of pancreatic malignant tumors using contrast-enhanced harmonic EUS (CEH-EUS) and to clarify the prognostic value of tumor vascularity in patients with locally advanced and metastatic pancreatic cancer. Hereby, we present the protocol of a prospective, nonrandomized, single-arm, multicenter study aiming to assess changes in tumor vascularity using CEH-EUS before and 2 months after treatment initiation in patients with unresectable, locally advanced/metastatic pancreatic cancer and to examine the correlation between vascular changes and treatment response, progression-free survival, and overall survival.

Indexed as

Contrast-enhanced endoscopicendoscopic ultrasoundpancreatic cancerprognosisultrasound

Identifiers

PMID31249159
PMCPMC6714481

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.