ArticleProceedings of the National Academy of Sciences of the United States of America2019
Crystal structure of jumping spider rhodopsin-1 as a light sensitive GPCR.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 42 citations in OpenAlex.
- Rhobot-Screen: an integrated robotic platform for functional screening of rhodopsin variants.BMC biology · 2026Article
- A multiscale screening platform for rapid GPCR variant profiling reveals color-tuned JSR1 mutants.Biophysical journal · 2026Article
- Mapping signal transduction in bistable jumping spider rhodopsin 1.Biophysical journal · 2026Article
- Dragonfly red opsins share a common tuning mechanism with mammalian red opsins and further enhancement of near-infrared sensitivity.Cellular and molecular life sciences : CMLS · 2026Article
- Peptide-based therapeutics targeting GPCRs: recent applications in the treatment of metabolic disorders.Frontiers in pharmacology · 2026Review
- Development of visible light-sensitive human neuropsin (OPN5) via single amino acid substitution.FEBS letters · 2025Article
- Cyclic peptide inhibitors function as molecular glues to stabilize Gq/11 heterotrimers.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Opsin gene expression plasticity and spectral sensitivity in male damselflies could mediate female colour morph detection.Proceedings. Biological sciences · 2025Article
- Ips typographus vision system: a comprehensive study.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Study of Photoselectivity in Linear Conjugated Chromophores Using the XMS-CASPT2 Method.ACS physical chemistry Au · 2024Article
- Active state structures of a bistable visual opsin bound to G proteins.Nature communications · 2024Article
- Evolution of Sensory Receptors.Annual review of cell and developmental biology · 2024Review
- In-silico predicted mouse melanopsins with blue spectral shifts deliver efficient subcellular signaling.Cell communication and signaling : CCS · 2024Article
- Activating an invertebrate bistable opsin with the all-trans 6.11 retinal analog.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Xport-A functions as a chaperone by stabilizing the first five transmembrane domains of rhodopsin-1.iScience · 2023Article
- Fluorescence of the Retinal Chromophore in Microbial and Animal Rhodopsins.International journal of molecular sciences · 2023Review
- Molecular Evolution of Malacostracan Short Wavelength Sensitive Opsins.Journal of molecular evolution · 2023Article
- Opsin Gene Duplication in Lepidoptera: Retrotransposition, Sex Linkage, and Gene Expression.Molecular biology and evolution · 2023Article
- Embedding Nonrigid Solutes in an Averaged Environment: A Case Study on Rhodopsins.Journal of chemical theory and computation · 2023Article
- Effect of Trace Metal Ions on the Conformational Stability of the Visual Photoreceptor Rhodopsin.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light-sensitive G protein-coupled receptors (GPCRs)-rhodopsins-absorb photons to isomerize their covalently bound retinal, triggering conformational changes that result in downstream signaling cascades. Monostable rhodopsins release retinal upon isomerization as opposed to the retinal in bistable rhodopsins that "reisomerize" upon absorption of a second photon. Understanding the mechanistic differences between these light-sensitive GPCRs has been hindered by the scarcity of recombinant models of the latter. Here, we reveal the high-resolution crystal structure of a recombinant bistable rhodopsin, jumping spider rhodopsin-1, bound to the inverse agonist 9-
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.