ArticleHaematologica2020
Megakaryocyte volume modulates bone marrow niche properties and cell migration dynamics.
Article in Haematologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Resilience of the bone marrow vascular architecture to aging and hematological stress.Blood vessels, thrombosis & hemostasis · 2026Article
- New insights into the generation and function of megakaryocytes in health and disease.Haematologica · 2025Review
- Neutrophil heterogeneity and plasticity: unveiling the multifaceted roles in health and disease.MedComm · 2025Review
- A modern overview of the process of platelet formation (thrombocytopoiesis) and its dependence on several factors.Biochemia medica · 2024Review
- MarShie: a clearing protocol for 3D analysis of single cells throughout the bone marrow at subcellular resolution.Nature communications · 2024Article
- Article
- Article
- Don't you forget about me(gakaryocytes).Blood · 2022Article
- Light sheet fluorescence microscopy as a new method for unbiased three-dimensional analysis of vascular injury.Cardiovascular research · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All hematopoietic cells that develop in the bone marrow must cross the endothelial barrier to enter the blood circulation. Blood platelets, however, are released by bigger protrusions of huge progenitor cells, named megakaryocytes, and enter the blood stream as so-called proplatelets before fragmenting into mature platelets. Recently, a second function of megakaryocytes has been identified, as they modulate the quiescence of hematopoietic stem cells, mostly via different soluble factors. We know from light sheet fluorescence microscopy images that megakaryocytes are distributed throughout the bone marrow facing a dense vascular network. Here, we used such three-dimensional images to provide a realistic simulation template reflecting the
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Registered trials
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