Evidence map›Paper›PMID 31248887›Full record

ArticleGenetics2019

Restoration of Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA in

Ashley B Williams, Felix Heider, Jan-Erik Messling, Matthias Rieckher, Wilhelm Bloch, Björn Schumacher

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Innate immunity in C. elegans.Current topics in developmental biology · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Ashley B WilliamsInstitute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931, Germany.ORCID 0000-0002-7558-9599
Felix HeiderInstitute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931, Germany.
Jan-Erik MesslingInstitute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931, Germany.
Matthias RieckherInstitute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931, Germany.
Wilhelm BlochDepartment of Molecular and Cellular Sports Medicine, German Sports University, 50933 Cologne, Germany.
Björn SchumacherInstitute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931, Germany bjoern.schumacher@uni-koeln.de.ORCID 0000-0001-6097-5238
Max Planck Institute for Biology of Ageing · DEUniversity of Cologne · DECologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases · DEGerman Sport University Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Innate immune responses protect organisms against various insults, but may lead to tissue damage when aberrantly activated. In higher organisms, cytoplasmic DNA can trigger inflammatory responses that can lead to tissue degeneration. Simpler metazoan models could shed new mechanistic light on how inflammatory responses to cytoplasmic DNA lead to pathologies. Here, we show that in a DNase II-defective

Indexed as

Immunity, InnateProteostasisAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDNAEndodeoxyribonucleasesEndoplasmic ReticulumCaenorhabditis elegans Proteinsdeoxyribonuclease IIDNAEndodeoxyribonucleasesCaenorhabditis elegansDNase IIDNA sensinginflammatory responsesinnate immunity

Identifiers

PMID31248887
PMCPMC6707470
OpenAlexW2953944496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.