Evidence map›Paper›PMID 31248690›Full record

ArticleJournal of autoimmunity2019

Ultraviolet light induces increased T cell activation in lupus-prone mice via type I IFN-dependent inhibition of T regulatory cells.

Sonya J Wolf, Shannon N Estadt, Jonathan Theros, Tyson Moore, Jason Ellis, Jianhua Liu, Tamra J Reed, Chaim O Jacob, Johann E Gudjonsson, J Michelle Kahlenberg

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of autoimmunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sonya J WolfDiv. of Rheumatology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Immunology Program, University of Michigan, Ann Arbor, MI, USA.
Shannon N EstadtDiv. of Rheumatology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Immunology Program, University of Michigan, Ann Arbor, MI, USA.
Jonathan TherosDiv. of Rheumatology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Tyson MooreDiv. of Rheumatology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Jason EllisImmunology Program, University of Michigan, Ann Arbor, MI, USA; Div. of Allergy and Immunology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Jianhua LiuDiv. of Rheumatology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Tamra J ReedDiv. of Rheumatology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Chaim O JacobUniversity of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Johann E GudjonssonDepartment of Dermatology, University of Michigan, Ann Arbor, MI, USA.
J Michelle KahlenbergDiv. of Rheumatology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. Electronic address: mkahlenb@med.umich.edu.
University of Michigan–Ann Arbor · USUniversity of Southern California · US

Funding

RESEARCH TRAINING IN EXPERIMENTAL IMMUNOPATHOLOGYT32AI007413 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bethany B. Moore · 1993 to 2026
$9.8M
University of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson · 2019 to 2026
$6.6M
Characterization of Interferon Kappa as a Novel Target in Cutaneous LupusR01AR071384 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joanne Michelle Kahlenberg · 2017 to 2026
$3.6M
Leukocyte NADPH Oxidase Variants in LupusR01AR072212 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JACOB, CHAIM O. · 2017 to 2022
$2.8M
The Role of Innate Immunity in Systemic and Cutaneous LupusK08AR063668 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAHLENBERG, JOANNE MICHELLE · 2013 to 2017
$736k
NIAID NIH HHS T32 AI007413NIAMS NIH HHS K08 AR063668NIAMS NIH HHS P30 AR075043NIAMS NIH HHS R01 AR071384NIAMS NIH HHS R01 AR072212
6 · The paper itself

Abstract

Ultraviolet (UV) light is a known trigger of skin and possibly systemic inflammation in systemic lupus erythematosus (SLE) patients. Although type I interferons (IFN) are upregulated in SLE skin after UV exposure, the mechanisms to explain increased UVB-induced inflammation remain unclear. This paper compares the role of type I IFNs in regulating immune cell activation between wild-type and lupus-prone mice following UVB exposure. 10-week old female lupus-prone (NZM2328), wild-type (BALB/c) and iNZM mice (lack a functional type I IFN receptor on NZM2328 background) were treated on their dorsal skin with 100 mJ/cm

Indexed as

AnimalsCells, CulturedFemaleGene Expression RegulationHumansInflammationInterferon Type ILupus Erythematosus, SystemicLupus NephritisLymphocyte ActivationMiceMice, Inbred BALB CMice, Mutant StrainsRadiation ExposureSkinT-Lymphocytes, RegulatoryInterferon Type IInterferonSystemic lupusT cellsT(REGs)Ultraviolet light

Identifiers

PMID31248690
PMCPMC6708464
OpenAlexW2955638099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.