Evidence map›Paper›PMID 31248555›Full record

ReviewJournal of the American College of Cardiology2019

Vascular Cognitive Impairment and Dementia: JACC Scientific Expert Panel.

Costantino Iadecola, Marco Duering, Vladimir Hachinski, Anne Joutel, Sarah T Pendlebury, Julie A Schneider, Martin Dichgans

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the American College of Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 468 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
468citing papers in PubMed, 17 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05565976 phase2 / phase3unknown statusstarted 2020, after this paper: background citation

Dapagliflozin Effect in Cognitive Impairment in Stroke Trial

Ran2020Enrolled270Registered outcomes3Posted comparisons0ConditionsDementia, Vascular, Metabolic Syndrome, Mild Cognitive Impairment, Stroke, IschemicArmsAntidiabetic, Dapagliflozin 10mg Tab, Platelet Antiaggregant, Statins (Cardiovascular Agents)
PMID 33282811PMID 20204386PMID 23040716PMID 28095900PMID 28950419PMID 29016744PMID 29371333PMID 29446769PMID 29573529PMID 31236801PMID 31535829PMID 32115470other papers from this trial
Open the trial in the graph
NCT06836141 recruitingnot on this mapstarted 2025, after this paper: background citation

Silent Brain Infarcts in Spontaneous Intracerebral Hemorrhage as a Prognostic Biomarker for Vascular Contributions to Cognitive Impairment and Dementia (VCID)

Typeobservational_patient_registrySponsorRush University Medical CenterRan2025 to 2029Enrolled118ConditionsPrimary Intracerebral HemorrhageArmsMRI, Blood Draw, Cognitive Test
3 · Its place in the literature

Who cites it

468 citing papers in PubMed, 17 syntheses or guidelines pooled it.

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  9. Efficacy and safety ofFrontiers in pharmacology · 2026
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408 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Costantino IadecolaFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York. Electronic address: coi2001@med.cornell.edu.
Marco DueringInstitute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-Universität LMU, Munich, Germany.
Vladimir HachinskiDepartment of Clinical Neurological Sciences, Western University, London, Ontario, Canada.
Anne JoutelInstitute of Psychiatry and Neurosciences of Paris, INSERM U1266, Université Paris Descartes, Paris, France.
Sarah T PendleburyCentre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital and the University of Oxford, Oxford, United Kingdom.
Julie A SchneiderRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.
Martin DichgansInstitute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-Universität LMU, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

Funding

SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Overexpression of the amyloid precursor protein and cerebrovascular regulationR01NS037853 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Costantino Iadecola · 1998 to 2026
$10.6M
Characterizing the Behavior Profile of Healthy Cognitive AgingR01AG034374 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI PATRICIA A BOYLE · 2009 to 2026
$8.8M
Risk Factors, Pathology, and Clinical Expressions of ADRF1AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2014 to 2014
$6.0M
NO SYNTHASE GENE EXPRESSION AND CEREBRAL ISCHEMIC DAMAGER01NS034179 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 1995 to 2021
$5.5M
Dietary Sodium, Neurovascular Dysfunction and Cerebrovascular RiskR01NS095441 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 2016 to 2025
$4.7M
ApoE4 and mechanisms of diffuse white matter injuryR01NS100447 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 2016 to 2020
$3.5M
Hypertension and neurovascular dysfunctionR37NS089323 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 2015 to 2021
$3.1M
Epidemiologic Study of TDP-43 Pathology in Aging and DementiaR01AG042210 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI SCHNEIDER, JULIE A. · 2012 to 2018
$2.4M
Multimodal MRI biomarkers of small vessel disease for older persons with and without dementia.UH2NS100599 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI ARFANAKIS, KONSTANTINOS, SCHNEIDER, JULIE A. · 2016 to 2017
$2.2M
NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG034374NIA NIH HHS R01 AG042210NIA NIH HHS RF1 AG015819NINDS NIH HHS R01 NS034179NINDS NIH HHS R01 NS037853NINDS NIH HHS R01 NS095441NINDS NIH HHS R01 NS100447NINDS NIH HHS R37 NS089323NINDS NIH HHS UH2 NS100599
6 · The paper itself

Abstract

Cognitive impairment associated with aging has emerged as one of the major public health challenges of our time. Although Alzheimer's disease is the leading cause of clinically diagnosed dementia in Western countries, cognitive impairment of vascular etiology is the second most common cause and may be the predominant one in East Asia. Furthermore, alterations of the large and small cerebral vasculature, including those affecting the microcirculation of the subcortical white matter, are key contributors to the clinical expression of cognitive dysfunction caused by other pathologies, including Alzheimer's disease. This scientific expert panel provides a critical appraisal of the epidemiology, pathobiology, neuropathology, and neuroimaging of vascular cognitive impairment and dementia, and of current diagnostic and therapeutic approaches. Unresolved issues are also examined to shed light on new basic and clinical research avenues that may lead to mitigating one of the most devastating human conditions.

Indexed as

Cognitive DysfunctionDementia, VascularHumansAlzheimer’s diseasecerebral blood flowcognitive dysfunctionsmall vessel diseasestroke

Identifiers

PMID31248555
PMCPMC6719789

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.