ArticleBMC plant biology2019
OsZIP1 functions as a metal efflux transporter limiting excess zinc, copper and cadmium accumulation in rice.
Article in BMC plant biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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Who cites it
97 citing papers in PubMed.
- Article
- Article
- The Multidrug Resistance Protein OsMDR4 Is Involved in Cadmium Absorption in Rice (Plants (Basel, Switzerland) · 2026Article
- Article
- Natural genetic variations underlying iron and zinc uptake efficiency in rice under direct-seeded cultivation conditions.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Applications of Gene-Editing Technologies in Enhancing Crop Stress Resistance with Emphasis on Rice.Plants (Basel, Switzerland) · 2026Review
- DNA Methylation Dynamics in Plant Abiotic Stress Response: Mechanisms, Memory, and Breeding Applications.Genes · 2026Review
- Polyploidy and zinc nanoparticles enhanced cadmium tolerance by regulating antioxidants and transport proteins.Plant cell reports · 2026Article
- From paddy soil to dining table: biological biofortification of rice with zinc.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Review
- Domestication-Selected Promoter Insertion in WRKY17 Increases Cadmium Sensitivity in Apple.Plant biotechnology journal · 2026Article
- Epigenetic modifications in plant abiotic stress adaptation: towards climate-resilient and sustainable crop improvement.Frontiers in plant science · 2026Review
- Spatiotemporal Transcriptome Profiling Reveals Nutrient Transport Dynamics in Rice Nodes and Roots During Reproductive Development.International journal of molecular sciences · 2025Article
- Physio-biochemical and transcriptomic analysis reveals underlying mechanism of Cys-induced amelioration of Cd toxicity in maize.Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Molecular Evolution of Cu Transporters and Transcription Factors in Plant Response to Copper Stress.Plants (Basel, Switzerland) · 2025Review
- OsRF2b interacting with OsbZIP61 modulates nitrogen use efficiency and grain yield via heterodimers in rice.Plant biotechnology journal · 2025Article
- Navigating the genetic basis of cadmium accumulation: a comprehensive analysis of low-cadmium accumulation rice.Molecular breeding : new strategies in plant improvement · 2025Article
- Interactions of Fe, Mn, Zn, and Cd in Soil-Rice Systems: Implications for Reducing Cd Accumulation in Rice.Toxics · 2025Article
- An ABC transporter-mediated transport and metabolism of the pesticide bentazone in rice (Oryza sativa L.).Journal of advanced research · 2025Article
- A Review of Reducing Cadmium Pollution in the Rice-Soil System in China.Foods (Basel, Switzerland) · 2025Review
- Article
37 more citing papers are in PubMed but not listed here.
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8 authors.
Funding
Abstract
backgroundMetal homeostasis is critical for plant growth, development and adaptation to environmental stresses and largely governed by a variety of metal transporters. The plant ZIP (Zn-regulated transporter, Iron-regulated transporter-like Protein) family proteins belong to the integral membrane transporters responsible for uptake and allocation of essential and non-essential metals. However, whether the ZIP family members mediate metal efflux and its regulatory mechanism remains unknown.
resultsIn this report, we provided evidence that OsZIP1 is a metal-detoxified transporter through preventing excess Zn, Cu and Cd accumulation in rice. OsZIP1 is abundantly expressed in roots throughout the life span and sufficiently induced by excess Zn, Cu and Cd but not by Mn and Fe at transcriptional and translational levels. Expression of OsZIP-GFP fusion in rice protoplasts and tobacco leaves shows that OsZIP1 resides in the endoplasmic reticulum (ER) and plasma membrane (PM). The yeast (Saccharomyces cerevisiae) complementation test shows that expression of OsZIP1 reduced Zn accumulation. Transgenic rice overexpressing OsZIP1 grew better under excess metal stress but accumulated less of the metals in plants. In contrast, both oszip1 mutant and RNA interference (RNAi) lines accumulated more metal in roots and contributed to metal sensitive phenotypes. These results suggest OsZIP1 is able to function as a metal exporter in rice when Zn, Cu and Cd are excess in environment. We further identified the DNA methylation of histone H3K9me2 of OsZIP1 and found that OsZIP1 locus, whose transcribed regions imbed a 242 bp sequence, is demethylated, suggesting that epigenetic modification is likely associated with OsZIP1 function under Cd stress.
conclusionOsZIP1 is a transporter that is required for detoxification of excess Zn, Cu and Cd in rice.
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