ArticleJournal of the American Heart Association2019
Elevated Mitral Valve Pressure Gradient Is Predictive of Long-Term Outcome After Percutaneous Edge-to-Edge Mitral Valve Repair in Patients With Degenerative Mitral Regurgitation ( MR ), But Not in Functional MR.
Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Anticoagulation therapy and clinical outcomes following transcatheter mitral valve repair for patients with mitral regurgitation: A meta-analysis.Clinical cardiology · 2023Pooled it
- Clinical Failure After Mitral Transcatheter Edge-to-Edge Repair Mechanisms, Outcomes, and Management.Structural heart : the journal of the Heart Team · 2026Review
- Elevated Trans-mitral Pressure Gradient Predicts Surgery in Young People with Moderate-Severe Rheumatic Mitral Regurgitation.Pediatric cardiology · 2025Article
- Functional Mitral Regurgitation in the Transcatheter Era: Diagnostic and Therapeutic Pathways.Journal of personalized medicine · 2025Review
- [Short-term clinical efficacy of transcatheter edge-to-edge repair for moderate to severe mitral regurgitation].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025Article
- Intraprocedural mitral regurgitation and gradient: key determinants of transcatheter edge-to-edge repair outcomes for primary mitral regurgitation.Cardiovascular diagnosis and therapy · 2025Article
- Impact of pulmonary hypertension on outcomes after TEER in patients suffering from mitral regurgitation.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Findings from transoesophageal echocardiographic follow-up after mitral transcatheter edge-to-edge repair.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024Article
- Impact of Residual Transmitral Mean Pressure Gradient on Outcomes After Mitral Transcatheter Edge-to-Edge Repair.JACC. Advances · 2024Article
- Echocardiographic Profiling Predicts Clinical Outcomes After Mitral Transcatheter Edge-to-Edge Repair.Journal of the American Heart Association · 2024Article
- Outcomes and Complications of Mitral and Tricuspid Transcatheter Edge-to-edge Repair.Interventional cardiology (London, England) · 2024Review
- Contemporary treatment of mitral valve disease with transcatheter mitral valve implantation.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Improved mid-term stability of MR reduction with an increased number of clips after percutaneous mitral valve repair in functional MR.International journal of cardiology. Heart & vasculature · 2023Article
- Transcatheter Edge-to-Edge Repair of Mitral Valve Regurgitation: Closing the Gap to Broaden the Coverage.Reviews in cardiovascular medicine · 2023Review
- Three-dimensional echocardiography for predicting mitral stenosis after MitraClip for functional mitral regurgitation.Journal of echocardiography · 2022Article
- Real-world anticoagulatory treatment after percutaneous mitral valve repair using MitraClip: a retrospective, observational study on 1300 patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Observational
- Flow adjusted transmitral pressure gradient as a modified indicator of functional mitral stenosis after repair for degenerative mitral regurgitation.Journal of cardiac surgery · 2022Article
- Effects of MitraClip Therapy on Mitral Flow Patterns and Vortex Formation: An In Vitro Study.Annals of biomedical engineering · 2022Article
- Transcatheter edge-to-edge mitral valve repair in patients with mitral annulus calcification.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2022Article
- Immediate Post-Procedural and Discharge Assessment of Mitral Valve Function Following Transcatheter Edge-to-Edge Mitral Valve Repair: Correlation and Association with Outcomes.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background This study analyzed the effects on long-term outcome of residual mitral regurgitation ( MR ) and mean mitral valve pressure gradient ( MVPG ) after percutaneous edge-to-edge mitral valve repair using the MitraClip system. Methods and Results Two hundred fifty-five patients who underwent percutaneous edge-to-edge mitral valve repair were analyzed. Kaplan-Meier and Cox regression analyses were performed to evaluate the impact of residual MR and MVPG on clinical outcome. A combined clinical end point (all-cause mortality, MV surgery, redo procedure, implantation of a left ventricular assist device) was used. After percutaneous edge-to-edge mitral valve repair, mean MVPG increased from 1.6±1.0 to 3.1±1.5 mm Hg ( P<0.001). Reduction of MR severity to ≤2+ postintervention was achieved in 98.4% of all patients. In the overall patient cohort, residual MR was predictive of the combined end point while elevated MVPG >4.4 mm Hg was not according to Kaplan-Meier and Cox regression analyses. We then analyzed the cohort with degenerative and that with functional MR separately to account for these different entities. In the cohort with degenerative MR , elevated MVPG was associated with increased occurrence of the primary end point, whereas this was not observed in the cohort with functional MR . Conclusions MVPG >4.4 mm Hg after MitraClip implantation was predictive of clinical outcome in the patient cohort with degenerative MR . In the patient cohort with functional MR , MVPG >4.4 mm Hg was not associated with increased clinical events.
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