GuidelineNutrients2019
Prevention of Allergic Sensitization and Treatment of Cow's Milk Protein Allergy in Early Life: The Middle-East Step-Down Consensus.
Guideline in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Are Management Strategies Associated with Tolerance Acquisition in Infants with Cow's Milk-Induced Allergic Proctocolitis?Journal of clinical medicine · 2026Article
- Clinical, laboratory, and therapeutic differences between immunoglobulin E-mediated and non-immunoglobulin E-mediated cow's milk protein allergy in children.World journal of clinical pediatrics · 2025Article
- Evolutive Study of Dietary Aspects and Intestinal Microbiota of Pediatric Cohort with Cow's Milk Protein Allergy.Children (Basel, Switzerland) · 2024Article
- How consistent are the key recommendations, and what is the quality of guidelines and expert consensus regarding paediatric cow's milk protein allergy?European journal of pediatrics · 2024Article
- [Expert consensus on enteral nutrition management for preterm infants in special situations (2024)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Impacts of people at-risk of either cow milk allergies or lactose intolerance on their daily calcium intake and bone mineral density.Frontiers in nutrition · 2024Article
- Symptoms and management of cow's milk allergy: perception and evidence.Frontiers in allergy · 2024Article
- Knowledge and Attitude of Community Pharmacists Toward Cow Milk Protein Allergy Complications and Treatment in Children: A Cross-Sectional Study in Sudan.Integrated pharmacy research & practice · 2024Article
- Prevalence and Risk Factors for IgE and IgG Cow's Milk Protein Allergies in Saudi Arabia.Cureus · 2023Article
- Article
- A systematic review of quality and consistency of clinical practice guidelines on the primary prevention of food allergy and atopic dermatitis.The World Allergy Organization journal · 2023Article
- Cow's milk-induced gastrointestinal disorders: From infancy to adulthood.World journal of clinical pediatrics · 2022Article
- Causes of bloody stools in neonates: a case series report.Translational pediatrics · 2022Article
- Clinical Effect of Standardized Dietary Avoidance Therapy on Children with Milk Protein Allergy and Its Effect on Intestinal Flora.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Review
- Article
- An Observational Real-Life Study with a New Infant Formula in Infants with Functional Gastro-Intestinal Disorders.Nutrients · 2021Observational
- How Are Infants Suspected to Have Cow's Milk Allergy Managed? A Real World Study Report.Nutrients · 2021Article
- Current Guidelines and Future Strategies for the Management of Cow's Milk Allergy.Journal of asthma and allergy · 2021Review
- Retention of vitamin A after goat milk processing into cheese: a nutritional strategy.Journal of food science and technology · 2020Article
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Allergy risk has become a significant public health issue with increasing prevalence. Exclusive breastfeeding is recommended for the first six months of life, but this recommendation is poorly adhered to in many parts of the world, including the Middle-East region, putting infants at risk of developing allergic sensitization and disorders. When breastfeeding is not possible or not adequate, a partially hydrolyzed whey formula (pHF-W) has shown proven benefits of preventing allergy, mainly atopic eczema, in children with a genetic risk. Therefore, besides stimulating breastfeeding, early identification of infants at risk for developing atopic disease and replacing commonly used formula based on intact cow milk protein (CMP) with a clinically proven pHF-W formula is of paramount importance for allergy prevention. If the child is affected by cow's milk protein allergy (CMPA), expert guidelines recommend extensively hydrolyzed formula (eHF), or an amino acid formula (AAF) in case of severe symptoms. The Middle-East region has a unique practice of utilizing pHF-W as a step-down between eHF or AAF and intact CMP, which could be of benefit. The region is very heterogeneous with different levels of clinical practice, and as allergic disorders may be seen by healthcare professionals of different specialties with different levels of expertise, there is a great variability in preventive and treatment approaches within the region itself. During a consensus meeting, a new approach was discussed and unanimously approved by all participants, introducing the use of pHF-W in the therapeutic management of CMPA. This novel approach could be of worldwide benefit.
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