Evidence map›Paper›PMID 31247960›Full record

ArticleMolecules (Basel, Switzerland)2019

Antitussive and Anti-inflammatory Dual-active Agents Developed from Natural Product Lead Compound 1-Methylhydantoin.

Yang Xu, Fang Wang, Hongye Guo, Shihan Wang, Shuling Ni, Yan Zhou, Zhihan Wang, Huiwei Bao, Yongsheng Wang

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Anti-Inflammatory Activity of Cyclic Imide Derivatives.Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  2. Review
  3. Divergent access to 5,6,7-perifused cycles.Nature communications · 2023
    Article
  4. Article
  5. Article
  6. Acyclic Twisted Amides.Chemical reviews · 2021
    Review
  7. Antioxidant Activity Evaluation ofMolecules (Basel, Switzerland) · 2021
    Article
  8. Article
  9. Article
  10. Molecules (Basel, Switzerland) · 2020
    Article
  11. Review
  12. Quality Evaluation ofFoods (Basel, Switzerland) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yang XuSchool of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, China.
Fang WangCollege of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, China.ORCID 0000-0003-0871-3454
Hongye GuoSchool of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, China.
Shihan WangCollege of Chinese Medicine Materials, Jilin Agricultural University, Changchun 130118, China.
Shuling NiSchool of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, China.
Yan ZhouSchool of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, China.
Zhihan WangDepartment of Physical Sciences, Eastern New Mexico University, Portales, NM 88130, USA.
Huiwei BaoCollege of Pharmacy, Changchun University of Chinese Medicine, Changchun, Jilin 130117, China.
Yongsheng WangSchool of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, China. mikewangwys@outlook.com.
Jilin University · CNChangchun University of Chinese Medicine · CNEastern New Mexico University · USJilin Agricultural University · CN

Funding

Department of Science and Technology of Jilin Province 200705378
6 · The paper itself

Abstract

Natural products play an important role in drug discovery. This work employed a natural product 1-methylhydantoin as the lead compound to develop novel dual-active drugs. 1-Methylhydantoin was isolated from

Indexed as

AnimalsAnti-Inflammatory AgentsAntitussive AgentsBiological ProductsCyclooxygenase 1Cyclooxygenase 2Drug DesignDrugs, Chinese HerbalHydantoinsMiceMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureProtein BindingStructure-Activity Relationship1-methylhydantoinAnti-Inflammatory AgentsAntitussive AgentsBiological ProductsCyclooxygenase 1Cyclooxygenase 2Drugs, Chinese HerbalHydantoins1-methylhydantoinacute pneumoniaanti-inflammatoryantitussivedual-activenatural productOviductus Ranae

Identifiers

PMID31247960
PMCPMC6651114
OpenAlexW2954650024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.