ArticleCells2019
Defocused Image Changes Signaling of Ganglion Cells in the Mouse Retina.
Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Defocus Incorporated Multiple Segments Spectacle Lenses Changed the Relative Peripheral Refraction: A 2-Year Randomized Clinical Trial.Investigative ophthalmology & visual science · 2020Trial
- Mechanisms Underlying Myopia Progression from Visual Signaling to Metabolic Remodeling in Retina.JMA journal · 2025Review
- Impact of phakic intraocular lens implantation on anxiety and depression in patients with high myopia.World journal of psychiatry · 2025Article
- Correlation Between Relative Peripheral Refraction and Efficacy of Myopia Control After Wearing Multifocal Soft Contact Lenses in Children.Ophthalmology and therapy · 2025Article
- The role of the KEAP1-NRF2 signaling pathway in form deprivation myopia guinea pigs.BMC ophthalmology · 2024Article
- Update on central factors in myopia development beyond intraocular mechanisms.Frontiers in neurology · 2024Review
- Widespread Involvement of Acetylation in the Retinal Metabolism of Form-Deprivation Myopia in Guinea Pigs.ACS omega · 2023Article
- The Role of Retinal Dysfunction in Myopia Development.Cellular and molecular neurobiology · 2023Review
- Assessment of Murine Retinal Acuity Ex Vivo Using Multielectrode Array Recordings.Translational vision science & technology · 2023Article
- The correlation between modifications to corneal topography and changes in retinal vascular density and retinal thickness in myopic children after undergoing orthokeratology.Frontiers in medicine · 2023Article
- Electroretinogram responses in myopia: a review.Documenta ophthalmologica. Advances in ophthalmology · 2022Review
- Functional connexin35 increased in the myopic chicken retina.Visual neuroscience · 2021Article
- IMI 2021 Yearly Digest.Investigative ophthalmology & visual science · 2021Review
- The Effect of Low-Dose Atropine on Alpha Ganglion Cell Signaling in the Mouse Retina.Frontiers in cellular neuroscience · 2021Article
- Molecular Biology of Retinal Ganglion Cells.Cells · 2020Article
- Retinal Inputs to the Thalamus Are Selectively Gated by Arousal.Current biology : CB · 2020Article
- Astigmatic Defocus Leads to Short-Term Changes in Human Choroidal Thickness.Investigative ophthalmology & visual science · 2020Article
- Article
- Increased Connexin36 Phosphorylation in AII Amacrine Cell Coupling of the Mouse Myopic Retina.Frontiers in cellular neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myopia is a substantial public health problem worldwide. Although it is known that defocused images alter eye growth and refraction, their effects on retinal ganglion cell (RGC) signaling that lead to either emmetropization or refractive errors have remained elusive. This study aimed to determine if defocused images had an effect on signaling of RGCs in the mouse retina. ON and OFF alpha RGCs and ON-OFF RGCs were recorded from adult C57BL/6J wild-type mice. A mono green organic light-emitting display presented images generated by PsychoPy. The defocused images were projected on the retina under a microscope. Dark-adapted mouse RGCs were recorded under different powers of projected defocused images on the retina. Compared with focused images, defocused images showed a significantly decreased probability of spikes. More than half of OFF transient RGCs and ON sustained RGCs showed disparity in responses to the magnitude of plus and minus optical defocus (although remained RGCs we tested exhibited similar response to both types of defocus). ON and OFF units of ON-OFF RGCs also responded differently in the probability of spikes to defocused images and spatial frequency images. After application of a gap junction blocker, the probability of spikes of RGCs decreased with the presence of optical defocused image. At the same time, the RGCs also showed increased background noise. Therefore, defocused images changed the signaling of some ON and OFF alpha RGCs and ON-OFF RGCs in the mouse retina. The process may be the first step in the induction of myopia development. It appears that gap junctions also play a key role in this process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.