Evidence map›Paper›PMID 31247945›Full record

SynthesisNutrients2019

Diurnal Variation of Markers for Cholesterol Synthesis, Cholesterol Absorption, and Bile Acid Synthesis: A Systematic Review and the Bispebjerg Study of Diurnal Variations.

Maite M Schroor, Henriette P Sennels, Jan Fahrenkrug, Henrik L Jørgensen, Jogchum Plat, Ronald P Mensink

Registry-linked trialOpen access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06166368 (the Bispebjerg Study of Diurnal Variations), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06166368 nacompletednot on this map

the Bispebjerg Study of Diurnal Variations

TypeinterventionalSponsorBispebjerg HospitalRan2008 to 2009Enrolled24ConditionsDiurnalArmsDiurnal variation
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Maite M SchroorDepartment of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 MD Maastricht, The Netherlands. maite.schroor@maastrichtuniversity.nl.
Henriette P SennelsDepartment of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Bispebjerg Bakke 23, DK-2400, Copenhagen NV, Denmark. henriette.pia.sennels@regionh.dk.
Jan FahrenkrugDepartment of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Bispebjerg Bakke 23, DK-2400, Copenhagen NV, Denmark. jan.fahrenkrug@regionh.dk.
Henrik L JørgensenDepartment of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200, Copenhagen N, Denmark. hlj@dadlnet.dk.
Jogchum PlatDepartment of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 MD Maastricht, The Netherlands. j.plat@maastrichtuniversity.nl.
Ronald P MensinkDepartment of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 MD Maastricht, The Netherlands. r.mensink@maastrichtuniversity.nl.
Maastricht University · NLFrederiksberg Hospital · DKHvidovre Hospital · DKUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human studies have shown diurnal rhythms of cholesterol and bile acid synthesis, but a better understanding of the role of the circadian system in cholesterol homeostasis is needed for the development of targeted interventions to improve metabolic health. Therefore, we performed a systematic literature search on the diurnal rhythms of cholesterol synthesis and absorption markers and of bile acid synthesis markers. We also examined the diurnal rhythms of the cholesterol synthesis markers lathosterol and desmosterol, and of the cholesterol absorption markers cholestanol, campesterol, and sitosterol in serum samples from the Bispebjerg study. These samples were collected every three hours over a 24-hour period in healthy males (

Indexed as

Circadian RhythmIntestinal AbsorptionAdolescentAdultBile Acids and SaltsBiomarkersCholestanolCholesterolDesmosterolFemaleHumansMaleMiddle AgedPhytosterolsSitosterolsTime FactorsBile Acids and SaltsBiomarkerscampesterolCholestanolCholesterolDesmosterolgamma-sitosterollathosterolPhytosterolsSitosterolsbile acid synthesischolesterol absorptioncholesterol synthesiscircadian systemdiurnal rhythms

Identifiers

PMID31247945
PMCPMC6683063
OpenAlexW2954442538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.