Evidence map›Paper›PMID 31247891›Full record

ArticleMolecules (Basel, Switzerland)2019

Cathepsin L Inhibitors with Activity against the Liver Fluke Identified From a Focus Library of Quinoxaline 1,4-di-

Florencia Ferraro, Alicia Merlino, Jorge Gil, Hugo Cerecetto, Ileana Corvo, Mauricio Cabrera

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Florencia FerraroLaboratorio de I + D de Moléculas Bioactivas, Departamento de Ciencias Biológicas, CENUR Litoral Norte, Universidad de la República, Paysandú 60000, Uruguay.ORCID 0000-0002-0865-8507
Alicia MerlinoLaboratorio de Química Teórica y Computacional, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, Montevideo 11400, Uruguay.
Jorge GilLaboratorio de Reproducción Animal, Producción y Reproducción de Rumiantes, Departamento de Ciencias Biológicas, CENUR Litoral Norte-Facultad de Veterinaria, Universidad de la República, Paysandú 60000, Uruguay.
Hugo CerecettoGrupo de Química Medicinal, Laboratorio de Química Orgánica & Área de Radiofarmacia, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Montevideo 11400, Uruguay.ORCID 0000-0003-1256-3786
Ileana CorvoLaboratorio de I + D de Moléculas Bioactivas, Departamento de Ciencias Biológicas, CENUR Litoral Norte, Universidad de la República, Paysandú 60000, Uruguay. ilecorvo@gmail.com.
Mauricio CabreraLaboratorio de I + D de Moléculas Bioactivas, Departamento de Ciencias Biológicas, CENUR Litoral Norte, Universidad de la República, Paysandú 60000, Uruguay. macabrera@fcien.edu.uy.ORCID 0000-0002-1709-0474
Universidad de la República de Uruguay · UY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infections caused by

Indexed as

AnimalsBinding SitesCathepsin LCattleDose-Response Relationship, DrugDrug Evaluation, PreclinicalFasciola hepaticaHumansInhibitory Concentration 50MaleModels, MolecularMolecular StructureProtein BindingProtein ConformationQuinoxalinesSpermatozoaCathepsin LquindoxinQuinoxalinescathepsin LFasciola hepaticamolecular dockingquinoxaline 1,4-di-N-oxidessmall molecule inhibitors

Identifiers

PMID31247891
PMCPMC6651555
OpenAlexW2954897031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.