Evidence map›Paper›PMID 31247773›Full record

ArticleOrganic letters2019

Total Synthesis of an Immunogenic Trehalose Phospholipid from Salmonella Typhi and Elucidation of Its sn-Regiochemistry by Mass Spectrometry.

Vivek K Mishra, Jeffrey Buter, Molly S Blevins, Martin D Witte, Ildiko Van Rhijn, D Branch Moody, Jennifer S Brodbelt, Adriaan J Minnaard

Open access · hybridAbstract read
In one paragraph

Article in Organic letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. A Cardiolipin fromJournal of the American Chemical Society · 2023
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Vivek K MishraStratingh Institute for Chemistry , University of Groningen , Nijenborgh 7 , 9747 AG Groningen , The Netherlands.
Jeffrey ButerStratingh Institute for Chemistry , University of Groningen , Nijenborgh 7 , 9747 AG Groningen , The Netherlands.
Molly S BlevinsDepartment of Chemistry , University of Texas , Austin , Texas 78712 , United States.
Martin D WitteStratingh Institute for Chemistry , University of Groningen , Nijenborgh 7 , 9747 AG Groningen , The Netherlands.ORCID 0000-0003-4660-2974
Ildiko Van RhijnDepartment of Infectious Diseases and Immunology, School of Veterinary Medicine , Utrecht University , 3584 CL Utrecht , The Netherlands.
D Branch MoodyDepartment of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital , Harvard Medical School , Boston , Massachusetts 02115 , United States.
Jennifer S BrodbeltDepartment of Chemistry , University of Texas , Austin , Texas 78712 , United States.
Adriaan J MinnaardStratingh Institute for Chemistry , University of Groningen , Nijenborgh 7 , 9747 AG Groningen , The Netherlands.ORCID 0000-0002-5966-1300
University of Groningen · NLBrigham and Women's Hospital · USThe University of Texas at Austin · US

Funding

Role of Tuberculosinyl Metabolites in M. Tuberculosis VirulenceR01AI116604 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH · 2015 to 2019
$2.4M
UVPD-MS Characterization of LipopolysaccharidesR01GM103655 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI BRODBELT, JENNIFER S. · 2012 to 2019
$2.3M
NIAID NIH HHS R01 AI116604NIGMS NIH HHS R01 GM103655
6 · The paper itself

Abstract

Diphosphatidyltrehalose (diPT) is an immunogenic glycolipid, recently isolated from Salmonella Typhi. Despite rigorous structure elucidation, the sn-position of the acyl chains on the glycerol backbone had not been unequivocally established. A stereoselective synthesis of diPT and its regioisomer is reported herein. Using a hybrid MS

Indexed as

Chemistry Techniques, SyntheticMass SpectrometryPhospholipidsSalmonella typhiStereoisomerismTrehalosePhospholipidsTrehalose

Identifiers

PMID31247773
PMCPMC6614791
OpenAlexW2952549929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.