ArticleNeurobiology of aging2019
Mice heterozygous for the Cdh23/Ahl1 mutation show age-related deficits in auditory temporal processing.
Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Haploinsufficiency of Whrn Contributes to Progressive Sensorineural Hearing Loss in C57BL6 Mice.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Cdh23 Gene Mutation-Induced Vestibular Dysfunction in Mice: Abnormal Stereocilia Bundle and Otolith Development and Activation of p53/FoxO Signaling Pathway.Journal of molecular neuroscience : MN · 2025Article
- Limiting Hearing Loss in Transgenic Mouse Models.eNeuro · 2025Article
- Sound-evoked plasticity differentiates tinnitus from non-tinnitus mice.Frontiers in neuroscience · 2025Article
- Sst- and Vip-Cre mouse lines without age-related hearing loss.bioRxiv : the preprint server for biology · 2024Article
- Exome sequencing of families from Ghana reveals known and candidate hearing impairment genes.Communications biology · 2022Article
- Comparison of two behavioral tests for tinnitus assessment in mice.Frontiers in behavioral neuroscience · 2022Article
- Cholinergic boutons are closely associated with excitatory cells and four subtypes of inhibitory cells in the inferior colliculus.Journal of chemical neuroanatomy · 2021Article
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- Generation of a ChATHearing research · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A mutation in the Cdh23 gene is implicated in both syndromic and nonsyndromic hearing loss in humans and age-related hearing loss in C57BL/6 mice. It is generally assumed that human patients (as well as mouse models) only have a hearing loss phenotype if the mutation is homozygous. However, a major complaint for patients with a hearing disability is a reduced speech intelligibility that may be related to temporal processing deficits rather than just elevated thresholds. In this study, we used the amplitude modulation following response (AMFR) to test whether mice heterozygous for Cdh23
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