ArticleMagnetic resonance imaging2019
Significant correlations between human cortical bone mineral density and quantitative susceptibility mapping (QSM) obtained with 3D Cones ultrashort echo time magnetic resonance imaging (UTE-MRI).
Article in Magnetic resonance imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Ultrashort Echo Time Quantitative Susceptibility Source Separation in Musculoskeletal System: A Feasibility Study.Journal of imaging · 2026Article
- Effects of Motion in Ultrashort Echo Time Quantitative Susceptibility Mapping for Musculoskeletal Imaging.Journal of imaging · 2025Article
- Hemosiderin quantification in hemophilic arthropathy using quantitative magnetic resonance imaging.Scientific reports · 2025Article
- UTE MRI technical developments and applications in osteoporosis: a review.Frontiers in endocrinology · 2025Review
- Quantitative MRI methods for the assessment of structure, composition, and function of musculoskeletal tissues in basic research and preclinical applications.Magma (New York, N.Y.) · 2024Review
- Ultrasound attenuation of cortical bone correlates with biomechanical, microstructural, and compositional properties.European radiology experimental · 2024Article
- Bone Biomarkers Based on Magnetic Resonance Imaging.Seminars in musculoskeletal radiology · 2024Review
- Evaluation of gadolinium deposition in cortical bone using three-dimensional ultrashort echo time quantitative susceptibility mapping: A preliminary study.NMR in biomedicine · 2024Article
- Validation of an MR-based multimodal method for molecular composition and proton stopping power ratio determination usingPhysics in medicine and biology · 2023Article
- QSM Throughout the Body.Journal of magnetic resonance imaging : JMRI · 2023Review
- Article
- MRI-based porosity index (PI) and suppression ratio (SR) in the tibial cortex show significant differences between normal, osteopenic, and osteoporotic female subjects.Frontiers in endocrinology · 2023Article
- A new 3D phase unwrapping method by region partitioning and local polynomial modeling in abdominal quantitative susceptibility mapping.Frontiers in neuroscience · 2023Article
- Making the invisible visible-ultrashort echo time magnetic resonance imaging: Technical developments and applications.Applied physics reviews · 2022Review
- Magnetic Resonance Imaging Versus Computed Tomography for Three-Dimensional Bone Imaging of Musculoskeletal Pathologies: A Review.Journal of magnetic resonance imaging : JMRI · 2022Review
- Ultrashort Echo Time Magnetic Resonance Imaging Techniques: Met and Unmet Needs in Musculoskeletal Imaging.Journal of magnetic resonance imaging : JMRI · 2022Review
- Can magnetic resonance imaging accurately and reliably measure humeral cortical thickness?JSES international · 2022Article
- Feasibility of ultrashort echo time quantitative susceptibility mapping with a 3D cones trajectory in the human brain.Frontiers in neuroscience · 2022Article
- Simultaneous Quantitative Susceptibility Mapping of Articular Cartilage and Cortical Bone of Human Knee Joint Using Ultrashort Echo Time Sequences.Frontiers in endocrinology · 2022Article
- Ultrashort echo time Cones double echo steady state (UTE-Cones-DESS) for rapid morphological imaging of short TMagnetic resonance in medicine · 2021Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeQuantitative susceptibility mapping (QSM) MRI is a tool that can characterize changes in susceptibility, an intrinsic property which is associated with compositional changes in the tissue. Current QSM estimation of cortical bone is challenging because conventional clinical MRI cannot acquire signal in cortical bone. This study aimed to implement Cones 3D ultrashort echo time MRI (UTE-MRI) for ex vivo QSM measurements in human tibial cortical bone, investigating the correlations of QSM with volumetric intracortical bone mineral density (BMD). MATERIALS AND
methodsNine tibial midshaft cortical bone specimens (25 mm long specimens cut at the mid-point of tibial shaft, 67 ± 20 years old, 5 women and 4 men) were scanned on a clinical 3 T MRI scanner for QSM measurement. The specimens were also scanned on a high-resolution micro-computed tomography (μCT) scanner for volumetric BMD estimation. QSM and μCT results were compared at approximately nine regions of interest (ROIs) per specimen.
resultsAverage 3D UTE-MRI QSM showed significantly strong correlation with volumetric BMD (R = -0.82, P < 0.01) and bone porosity (R = 0.72, P < 0.01). Combining all data points together (77 ROIs), QSM showed significant moderate to strong correlation with volumetric BMD after correction for interdependencies in specimens (R = -0.70, P < 0.01). The corrections were required because the data points were not independent in each specimen. Similarly, the correlation between QSM and porosity was significant (R = 0.68, P < 0.01).
conclusionsThese results suggest that the Cones 3D UTE-MRI QSM technique can potentially serve as a novel and accurate tool to assess intracortical bone mineral density whilst avoiding ionizing radiation.
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