Evidence map›Paper›PMID 31247144›Full record

ArticleAmerican journal of respiratory cell and molecular biology2020

Metabolic Adaptation of Airway Smooth Muscle Cells to an SPHK2 Substrate Precedes Cytostasis.

Pascale Blais-Lecours, Sofien Laouafa, Christian Arias-Reyes, Webster L Santos, Vincent Joseph, Janette K Burgess, Andrew J Halayko, Jorge Soliz, David Marsolais

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. PD 102807 Induces M3 mAChR-Dependent GRK-/Arrestin-Biased Signaling in Airway Smooth Muscle Cells.American journal of respiratory cell and molecular biology · 2022
    Article
  2. Metabolomics in asthma: A platform for discovery.Molecular aspects of medicine · 2022
    Review
  3. Update in Adult Asthma 2020.American journal of respiratory and critical care medicine · 2021
    Review
  4. Review
  5. Increasing Sphingolipid Synthesis Alleviates Airway Hyperreactivity.American journal of respiratory cell and molecular biology · 2020
    Article
  6. Give Me Some Room to Breathe! Can Targeting SPHK2 Reduce Airway Smooth Muscle Thickening in Asthma?American journal of respiratory cell and molecular biology · 2020
    Article
  7. Airway Remodeling in Asthma.Frontiers in medicine · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Pascale Blais-LecoursCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec and.
Sofien LaouafaCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec and.
Christian Arias-ReyesCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec and.
Webster L SantosDepartment of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia.
Vincent JosephCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec and.
Janette K BurgessDepartment of Pathology and Medical Biology, Experimental Pulmonology and Inflammation Research and.
Andrew J HalaykoDepartment of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Manitoba, Canada; and.
Jorge SolizCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec and.
David MarsolaisCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec and.ORCID 0000-0002-8935-6657
Institut universitaire de cardiologie et de pneumologie de Québec · CAResearch Manitoba · CAUniversity Medical Center Groningen · NLVirginia Tech · US

Funding

MD-PHAR Controlling sphingosine 1-phosphate synthesis and traffickingR01GM121075 · NIGMS · UNIVERSITY OF VIRGINIA · PI LYNCH, KEVIN R., SANTOS, WEBSTER L · 2016 to 2020
$2.1M
CIHR 274357NIGMS NIH HHS R01 GM121075
6 · The paper itself

Abstract

Thickening of the airway smooth muscle is central to bronchial hyperreactivity. We have shown that the sphingosine analog (

Indexed as

AsthmaBronchial HyperreactivityCell LineCell ProliferationHumansLungMuscle, SmoothMyocytes, Smooth MusclePhosphotransferases (Alcohol Group Acceptor)Sphingosine KinasePhosphotransferases (Alcohol Group Acceptor)Sphingosine Kinasesphingosine kinase 2, humanAAL-RasthmaFTY720metabolismsphingolipids

Identifiers

PMID31247144
PMCPMC6938129
OpenAlexW2955136560

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.