ArticleInvestigative ophthalmology & visual science2019
Visual Cortical Plasticity in Retinitis Pigmentosa.
Article in Investigative ophthalmology & visual science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Fuzzing the brain: automated stress testing for the safety of ML-driven neurostimulation.Journal of neural engineering · 2026Article
- Enhancing Experience-Dependent Plasticity Accelerates Vision Loss in a Murine Model of Retinitis Pigmentosa.Investigative ophthalmology & visual science · 2026Article
- Restoring Vision with Noninvasive Brain Stimulation: A Narrative Review.Ophthalmology and therapy · 2025Review
- Adaptive changes in the visual cortex after photoreceptor degeneration in retinitis pigmentosa.Histology and histopathology · 2025Review
- Characterizing Inner Retinal Changes in End-Stage Inherited Retinal Diseases That Might be Suitable for Optogenetic Therapies.Translational vision science & technology · 2025Article
- Turning ON the inner retinal circuity: An exciting new approach to optogenetic therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- The interplay between Hebbian and homeostatic plasticity in the adult visual cortex.The Journal of physiology · 2025Article
- Long term adult visual plasticity after the developmental critical period in genetically determinedHeliyon · 2025Article
- 7 Tesla MRI Reveals Brain Structural Abnormalities and Neural Plasticity in RPGR-Related Retinitis Pigmentosa.Journal of clinical medicine · 2025Article
- Neural and Müller glial adaptation of the retina to photoreceptor degeneration.Neural regeneration research · 2023Review
- Retinitis Pigmentosa Associated with EYS Gene Mutations: Disease Severity Staging and Central Retina Atrophy.Diagnostics (Basel, Switzerland) · 2023Article
- Internal neural states influence the short-term effect of monocular deprivation in human adults.eLife · 2023Article
- Dynamic structural remodeling of the human visual system prompted by bilateral retinal gene therapy.Current research in neurobiology · 2023Article
- Implications of Neural Plasticity in Retinal Prosthesis.Investigative ophthalmology & visual science · 2022Article
- Transcranial random noise stimulation and exercise do not modulate ocular dominance plasticity in adults with normal vision.Journal of vision · 2022Article
- The shift in sensory eye dominance from short-term monocular deprivation exhibits no dependence on test spatial frequency.Eye and vision (London, England) · 2022Article
- Article
- Light-induced charge generation in polymeric nanoparticles restores vision in advanced-stage retinitis pigmentosa rats.Nature communications · 2022Article
- Progressive Retinal Degeneration Increases Cortical Response Latency of Light Stimulation but Not of Electric Stimulation.Translational vision science & technology · 2022Article
- The detrimental effects of progression of retinal degeneration in the visual cortex.Frontiers in cellular neuroscience · 2022Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Retinitis pigmentosa is a family of genetic diseases inducing progressive photoreceptor degeneration. There is no cure for retinitis pigmentosa, but prospective therapeutic strategies are aimed at restoring or substituting retinal input. Yet, it is unclear whether the visual cortex of retinitis pigmentosa patients retains plasticity to react to the restored visual input. Methods: To investigate short-term visual cortical plasticity in retinitis pigmentosa, we tested the effect of short-term (2 hours) monocular deprivation on sensory ocular dominance (measured with binocular rivalry) in a group of 14 patients diagnosed with retinitis pigmentosa with a central visual field sparing greater than 20° in diameter. Results: After deprivation most patients showed a perceptual shift in ocular dominance in favor of the deprived eye (P < 0.001), as did control subjects, indicating a level of visual cortical plasticity in the normal range. The deprivation effect correlated negatively with visual acuity (r = -0.63, P = 0.015), and with the amplitude of the central 18° focal electroretinogram (r = -0.68, P = 0.015) of the deprived eye, revealing that in retinitis pigmentosa stronger visual impairment is associated with higher plasticity. Conclusions: Our results provide a new tool to assess the ability of retinitis pigmentosa patients to adapt to altered visual inputs, and suggest that in retinitis pigmentosa the adult brain has sufficient short-term plasticity to benefit from prospective therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.