ArticlePloS one2019
Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- A deeper look at long-term effects of COVID-19 on myocardial function in survivors with no prior heart diseases: a GRADE approach systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2024Pooled it
- Article
- Extracorporeal Life Support in a Porcine Model of Septic Endotoxemia with Acute Pulmonary Hypertension: An Experimental Study.Journal of clinical medicine · 2025Article
- miR-361-3p overexpression promotes apoptosis and inflammation by regulating the USP49/IκBα/NF-κB pathway to aggravate sepsis-induced myocardial injury.Toxicology research · 2024Article
- Management and outcomes in pulmonary arterial hypertension patients with sepsis.BMC pulmonary medicine · 2024Article
- Femoral nailing associated with bone marrow emboli in pigs induced a specific increase in blood IL-6 and broad inflammatory responses in the heart and lungs.Frontiers in immunology · 2024Article
- Hospital outcomes for patients with pulmonary arterial hypertension in sepsis and septic shock.BMC pulmonary medicine · 2022Article
- Venous Air Embolism Activates Complement C3 Without Corresponding C5 Activation and Trigger Thromboinflammation in Pigs.Frontiers in immunology · 2022Article
- Effects of extracellular histones on left ventricular diastolic function and potential mechanisms in mice with sepsis.American journal of translational research · 2022Article
- MiR-539-5p inhibits the inflammatory injury in septic H9c2 cells by regulating IRAK3.Molecular biology reports · 2022Article
- Rethinking animal models of sepsis - working towards improved clinical translation whilst integrating the 3Rs.Clinical science (London, England : 1979) · 2020Review
- The etiological role of endoplasmic reticulum stress in acute lung injury-related right ventricular dysfunction in a rat model.American journal of translational research · 2020Article
- Right Ventricular Dysfunction Score in the Prognostic Evaluation of Patients with Sepsis and Septic Shock.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care MedicineArticle
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRight ventricular (RV) myocardial dysfunction is a common feature in septic shock. It can worsen outcome, but the etiology is poorly understood. Pulmonary artery hypertension (PAH) plays a part in the pathogenesis of the right heart dysfunction in sepsis but its importance is unknown. In pigs, PAH in sepsis is substantial and the translational value of porcine sepsis models therefore questioned. We hypothesized that porcine sepsis causes a myocardial inflammatory response which leads to myocardial dysfunction independent of PAH. MATERIALS AND
methodsSepsis was induced by Escherichia coli-infusion in 10 pigs resulting in PAH and increased right ventricular pressure (RVP). The same degree of RVP was achieved by external pulmonary artery banding (PAB) in a consecutive series of 6 animals.
resultsSepsis, but not PAB, led to increase in endothelial damage marker PAI-1 and cytokines TNF and IL-6 (all p<0.05) in plasma. In myocardium, TNF and IL-6 were significantly elevated in sepsis, TNF in both ventricles and IL-6 mostly in RV, while IL-1β, IL-18 and C5a were significantly higher in RV compared to LV after PAB (all p<0.05). Myocardial mRNA levels of IL-1β, IL-6, IL-18, IP-10, E-selectin and PAI-1 were significantly elevated in RV and LV during sepsis compared to PAB, while Caspase-1 was decreased in septic compared to PAB animals (all p<0.05). Cathepsin L activity was increased in RV by PAB, while sepsis inhibited this response. Escherichia coli-induced sepsis caused myocardial inflammation independent of PAH.
conclusionProminent PAH should therefore not exclude porcine sepsis models to further our understanding of human sepsis.
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