SynthesisPLoS neglected tropical diseases2019
One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia.
Synthesis in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 76 citations in OpenAlex.
- Iron Supplementation with Ferrous Sulfate or Ferrous Bisglycinate for 12 Weeks Does Not Influence Group B Streptococcus Colonization in Cambodian Women: A Secondary Analysis of a Randomized Controlled Trial.The Journal of nutrition · 2025Trial
- Bacterial targeting of the neutrophil inhibitory receptor LILRB3 to evade antibody immunity.Nature communications · 2026Article
- Article
- Consumption of raw or undercooked freshwater fish and awareness of risks of associated bacterial and parasitic infections in Southeast Asia: an online multicountry cross-sectional survey.BMJ public health · 2026Article
- Rapid detection ofFrontiers in microbiology · 2026Article
- Characterization and Genome Comparison of Bacteriophage KKU62-1 Infecting Hypervirulent Streptococcus agalactiae ST283.Current microbiology · 2025Article
- A large outbreak of invasive Group BEpidemiology and infection · 2025Article
- Predomination of hypervirulent ST283 and genetic diversity of levofloxacin resistance in multidrug-resistant, hypervirulentJournal of medical microbiology · 2025Article
- Severe Acute Bacterial Skin and Skin Structure Infection Following Fish Spine Injury: A Case Report and Literature Review.Infection and drug resistance · 2025Article
- Invasive Group B Streptococcus Infections Caused by Hypervirulent Clone of S. agalactiae Sequence Type 283, Hong Kong, China, 2021Emerging infectious diseases · 2025Article
- TwoFrontiers in microbiology · 2025Article
- Unveiling the genetic landscape of Streptococcus agalactiae bacteremia: emergence of hypervirulent CC1 strains and new CC283 strains in Tehran, Iran.BMC microbiology · 2024Article
- Genomic and functional determinants of host spectrum in Group B Streptococcus.PLoS pathogens · 2024Article
- A metagenomics-based workflow for the detection and genomic characterization of GBS in raw freshwater fish.Microbiology spectrum · 2024Article
- Emergence of Group B Streptococcus Disease in Pigs and Porcupines, Italy.Emerging infectious diseases · 2024Article
- Genomic Analysis of Group BOpen forum infectious diseases · 2023Article
- Human Fecal Carriage of Streptococcus agalactiae Sequence Type 283, Thailand.Emerging infectious diseases · 2023Article
- Comprehensive Characterization of aPharmaceuticals (Basel, Switzerland) · 2023Article
- Geographical, Temporal and Host-Species Distribution of Potentially Human-Pathogenic Group BPathogens (Basel, Switzerland) · 2023Article
- Article
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Authors and funding
30 authors at 20 institutions in 10 countries.
Funding
Abstract
backgroundIn 2015, Singapore had the first and only reported foodborne outbreak of invasive disease caused by the group B Streptococcus (GBS; Streptococcus agalactiae). Disease, predominantly septic arthritis and meningitis, was associated with sequence type (ST)283, acquired from eating raw farmed freshwater fish. Although GBS sepsis is well-described in neonates and older adults with co-morbidities, this outbreak affected non-pregnant and younger adults with fewer co-morbidities, suggesting greater virulence. Before 2015 ST283 had only been reported from twenty humans in Hong Kong and two in France, and from one fish in Thailand. We hypothesised that ST283 was causing region-wide infection in Southeast Asia. METHODOLOGY/PRINCIPAL
findingsWe performed a literature review, whole genome sequencing on 145 GBS isolates collected from six Southeast Asian countries, and phylogenetic analysis on 7,468 GBS sequences including 227 variants of ST283 from humans and animals. Although almost absent outside Asia, ST283 was found in all invasive Asian collections analysed, from 1995 to 2017. It accounted for 29/38 (76%) human isolates in Lao PDR, 102/139 (73%) in Thailand, 4/13 (31%) in Vietnam, and 167/739 (23%) in Singapore. ST283 and its variants were found in 62/62 (100%) tilapia from 14 outbreak sites in Malaysia and Vietnam, in seven fish species in Singapore markets, and a diseased frog in China.
conclusionsGBS ST283 is widespread in Southeast Asia, where it accounts for a large proportion of bacteraemic GBS, and causes disease and economic loss in aquaculture. If human ST283 is fishborne, as in the Singapore outbreak, then GBS sepsis in Thailand and Lao PDR is predominantly a foodborne disease. However, whether transmission is from aquaculture to humans, or vice versa, or involves an unidentified reservoir remains unknown. Creation of cross-border collaborations in human and animal health are needed to complete the epidemiological picture.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.