Evidence map›Paper›PMID 31246462›Full record

ArticleJournal of the American Chemical Society2019

Dual-Reactivity

Samuel L Scinto, Oshini Ekanayake, Uthpala Seneviratne, Jessica E Pigga, Samantha J Boyd, Michael T Taylor, Jun Liu, Christopher W Am Ende, Sharon Rozovsky, Joseph M Fox

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. A Crystalline and Thermally Stable Selenocysteine Selenenic Acid.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
  3. Review
  4. Minimalist TetrazineJournal of the American Chemical Society · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Flow Photochemical Syntheses ofIsrael journal of chemistry · 2020
    Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samuel L ScintoDepartment of Chemistry and Biochemistry , University of Delaware , Newark , Delaware 19716 , United States.
Oshini EkanayakeDepartment of Chemistry and Biochemistry , University of Delaware , Newark , Delaware 19716 , United States.
Uthpala SeneviratnePfizer Worldwide Research and Development , Cambridge , Massachusetts 02139 , United States.
Jessica E PiggaDepartment of Chemistry and Biochemistry , University of Delaware , Newark , Delaware 19716 , United States.
Samantha J BoydDepartment of Chemistry and Biochemistry , University of Delaware , Newark , Delaware 19716 , United States.
Michael T TaylorDepartment of Chemistry and Biochemistry , University of Delaware , Newark , Delaware 19716 , United States.
Jun LiuDepartment of Chemistry and Biochemistry , University of Delaware , Newark , Delaware 19716 , United States.ORCID 0000-0003-1766-0411
Christopher W Am EndePfizer Worldwide Research and Development , Groton , Connecticut 06340 , United States.ORCID 0000-0001-8832-9641
Sharon RozovskyDepartment of Chemistry and Biochemistry , University of Delaware , Newark , Delaware 19716 , United States.ORCID 0000-0003-4902-0777
Joseph M FoxDepartment of Chemistry and Biochemistry , University of Delaware , Newark , Delaware 19716 , United States.ORCID 0000-0002-8258-1640

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Gregory E Hicks · 2013 to 2026
$60.5M
This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI SCHMITZ, KARL ROBERT · 2014 to 2024
$26.8M
Pilot Research Subproject ProgramP30GM110758 · NIGMS · UNIVERSITY OF DELAWARE · PI PATEL, SANDEEP · 2014 to 2018
$5.8M
CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAININGT32GM008550 · NIGMS · UNIVERSITY OF DELAWARE · PI BAHNSON, BRIAN J · 1994 to 2018
$5.0M
Toolkit for Fast, Multipurpose and Inducible Bioorthogonal ChemistryR01GM132460 · NIGMS · UNIVERSITY OF DELAWARE · PI JOSEPH M FOX · 2019 to 2026
$4.2M
Chemistry-Biology Interface Predoctoral Training Grant 2024-2029T32GM133395 · NIGMS · UNIVERSITY OF DELAWARE · PI Catherine Leimkuhler Grimes · 2019 to 2026
$3.7M
Selenoproteins in the ER-associated protein degradation pathwayR01GM121607 · NIGMS · UNIVERSITY OF DELAWARE · PI ROZOVSKY, SHARON · 2017 to 2021
$1.1M
Q-Exactive Orbitrap LC-MC/MS SystemS10OD016267 · OD · UNIVERSITY OF DELAWARE · PI JOHNSTON, MURRAY V · 2013 to 2013
$573k
High Performance Digital NMR SpectrometerS10RR026962 · NCRR · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2010 to 2010
$500k
NCRR NIH HHS S10 RR026962NIGMS NIH HHS P20 GM104316NIGMS NIH HHS P30 GM110758NIGMS NIH HHS R01 GM121607NIGMS NIH HHS R01 GM132460NIGMS NIH HHS T32 GM008550NIGMS NIH HHS T32 GM133395NIGMS NIH HHS U54 GM104941NIH HHS S10 OD016267
6 · The paper itself

Abstract

Sulfenylation (RSH → RSOH) is a post-translational protein modification associated with cellular mechanisms for signal transduction and the regulation of reactive oxygen species. Protein sulfenic acids are challenging to identify and study due to their electrophilic and transient nature. Described here are sulfenic acid modifying

Indexed as

BiotinCycloparaffinsHEK293 CellsHumansMolecular ProbesMolecular StructureStereoisomerismSulfenic AcidsBiotinCycloparaffinsMolecular ProbesSulfenic Acids

Identifiers

PMID31246462
PMCPMC6756850

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.