ArticleACS chemical biology2019
Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging
Open access · greenAbstract read
In one paragraph
Article in ACS chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- A New Soaking Protocol to Live StainbioRxiv : the preprint server for biology · 2026Article
- Non-Mammalian Models for Mitochondria Research in CNS Disorders.Biomolecules · 2026Review
- Multi-parameter fluorescence lifetime imaging for high-noise neuroscience applications.Biomedical optics express · 2026Article
- Article
- Deep Learning for Fluorescence Lifetime Predictions Enables High-Throughput In Vivo Imaging.Journal of the American Chemical Society · 2025Article
- FLIMPA: A Versatile Software for Fluorescence Lifetime Imaging Microscopy Phasor Analysis.Analytical chemistry · 2025Article
- Mechanisms of Alpha-Synuclein-Seeded Aggregation in Neurons Revealed by Fluorescence Lifetime Imaging.ACS chemical neuroscience · 2025Article
- The role of RNA in the nanoscale organization of α-synuclein phase separation.NAR molecular medicine · 2025Article
- Dissecting aggregation and seeding dynamics of α-Syn polymorphs using the phasor approach to FLIM.Communications biology · 2022Article
- Modulating biomolecular condensates: a novel approach to drug discovery.Nature reviews. Drug discovery · 2022Review
- De novo designed protein inhibitors of amyloid aggregation and seeding.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dynamic Mode Decomposition of Fluorescence Loss in Photobleaching Microscopy Data for Model-Free Analysis of Protein Transport and Aggregation in Living Cells.Sensors (Basel, Switzerland) · 2022Article
- Molecular mechanisms of amyloid formation in living systems.Chemical science · 2022Review
- Exploiting flow cytometry for the unbiased quantification of protein inclusions in Caenorhabditis elegans.Journal of neurochemistry · 2022Article
- Using aPharmaceuticals (Basel, Switzerland) · 2022Article
- A FRET-based method for monitoring structural transitions in protein self-organization.Cell reports methods · 2022Article
- Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies.Journal of molecular cell biology · 2021Article
- Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Comparative Studies in the A30P and A53T α-SynucleinFrontiers in cell and developmental biology · 2021Article
- Characterization of Amyloid Structures in Aging C. Elegans Using Fluorescence Lifetime Imaging.Journal of visualized experiments : JoVE · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Romain F LaineLaser Analytics Group, Department of Chemical Engineering and Biotechnology , University of Cambridge , Cambridge CB3 0AS , United Kingdom.ORCID 0000-0002-2151-4487
Tessa SinnigeCentre for Misfolding Diseases, Department of Chemistry , University of Cambridge , Cambridge CB2 1EW , United Kingdom.ORCID 0000-0002-9353-126X
Kai Yu MaCentre for Misfolding Diseases, Department of Chemistry , University of Cambridge , Cambridge CB2 1EW , United Kingdom.
Amanda J HaackLaser Analytics Group, Department of Chemical Engineering and Biotechnology , University of Cambridge , Cambridge CB3 0AS , United Kingdom.
Chetan PoudelLaser Analytics Group, Department of Chemical Engineering and Biotechnology , University of Cambridge , Cambridge CB3 0AS , United Kingdom.ORCID 0000-0002-8512-9238
Peter GaidaLaser Analytics Group, Department of Chemical Engineering and Biotechnology , University of Cambridge , Cambridge CB3 0AS , United Kingdom.
Nathan CurryLaser Analytics Group, Department of Chemical Engineering and Biotechnology , University of Cambridge , Cambridge CB3 0AS , United Kingdom.
Michele PerniCentre for Misfolding Diseases, Department of Chemistry , University of Cambridge , Cambridge CB2 1EW , United Kingdom.ORCID 0000-0001-7593-8376
Ellen A A NollenEuropean Research Institute for the Biology of Ageing , University Medical Centre Groningen , 9700 AD Groningen , The Netherlands.
Christopher M DobsonCentre for Misfolding Diseases, Department of Chemistry , University of Cambridge , Cambridge CB2 1EW , United Kingdom.
Michele VendruscoloCentre for Misfolding Diseases, Department of Chemistry , University of Cambridge , Cambridge CB2 1EW , United Kingdom.ORCID 0000-0002-3616-1610
Gabriele S Kaminski SchierleMolecular Neuroscience Group, Department of Chemical Engineering and Biotechnology , University of Cambridge , Cambridge CB3 0AS , United Kingdom.ORCID 0000-0002-1843-2202
Clemens F KaminskiLaser Analytics Group, Department of Chemical Engineering and Biotechnology , University of Cambridge , Cambridge CB3 0AS , United Kingdom.ORCID 0000-0002-5194-0962
University of Cambridge · GB
Funding
Biotechnology and Biological Sciences Research Council BB/P027431/1Biotechnology and Biological Sciences Research Council BB/R021805/1Medical Research Council MR/K015850/1Medical Research Council MR/K02292X/1Wellcome Trust 089703/Z/09/ZWellcome Trust 203249Wellcome Trust 203249/Z/16/ZWellcome Trust 3-3249/Z/16/Z
Abstract
The nematode worm
Indexed as
Protein AggregatesAgingalpha-SynucleinAmyloidAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsOptical ImagingPeptidesalpha-SynucleinAmyloidCaenorhabditis elegans ProteinsPeptidespolyglutamineProtein Aggregates
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.