Evidence map›Paper›PMID 31246412›Full record

ArticleACS nano2019

Biodegradable Biliverdin Nanoparticles for Efficient Photoacoustic Imaging.

Parinaz Fathi, Hailey J Knox, Dinabandhu Sar, Indu Tripathi, Fatemeh Ostadhossein, Santosh K Misra, Mandy B Esch, Jefferson Chan, Dipanjan Pan

Abstract read
In one paragraph

Article in ACS nano, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Bilirubin metabolism and its application in disease prevention: mechanisms and research advances.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  5. Biodegradable ICG-Conjugated Germanium Nanoparticles forACS applied materials & interfaces · 2024
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Information Entropy as a Reliable Measure of Nanoparticle Dispersity.Chemistry of materials : a publication of the American Chemical Society · 2020
    Article
  19. Systemic Review of Biodegradable Nanomaterials in Nanomedicine.Nanomaterials (Basel, Switzerland) · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Parinaz FathiDepartments of Bioengineering, Materials Science and Engineering, and Beckman Institute , University of Illinois , Urbana , Illinois 61801 , United States.
Hailey J KnoxDepartment of Chemistry and Beckman Institute , University of Illinois , Urbana , Illinois 61801 , United States.ORCID 0000-0003-0608-2855
Dinabandhu SarDepartments of Bioengineering, Materials Science and Engineering, and Beckman Institute , University of Illinois , Urbana , Illinois 61801 , United States.
Indu TripathiDepartments of Bioengineering, Materials Science and Engineering, and Beckman Institute , University of Illinois , Urbana , Illinois 61801 , United States.
Fatemeh OstadhosseinDepartments of Bioengineering, Materials Science and Engineering, and Beckman Institute , University of Illinois , Urbana , Illinois 61801 , United States.ORCID 0000-0003-4213-7948
Santosh K MisraDepartments of Bioengineering, Materials Science and Engineering, and Beckman Institute , University of Illinois , Urbana , Illinois 61801 , United States.ORCID 0000-0002-3313-4895
Mandy B EschBiomedical Technologies Group, Microsystems and Nanotechnology Division, Physical Measurement Laboratory , National Institute of Standards and Technology , Gaithersburg , Maryland 20899 , United States.
Jefferson ChanDepartment of Chemistry and Beckman Institute , University of Illinois , Urbana , Illinois 61801 , United States.ORCID 0000-0003-4139-4379
Dipanjan PanDepartments of Bioengineering, Materials Science and Engineering, and Beckman Institute , University of Illinois , Urbana , Illinois 61801 , United States.ORCID 0000-0003-0175-4704

Funding

Tissue microenvironment (TIMe) training programT32EB019944 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BHARGAVA, ROHIT, GASKINS, REX · 2016 to 2025
$1.9M
NIBIB NIH HHS T32 EB019944
6 · The paper itself

Abstract

Photoacoustic imaging has emerged as a promising imaging platform with a high tissue penetration depth. However, biodegradable nanoparticles, especially those for photoacoustic imaging, are rare and limited to a few polymeric agents. The development of such nanoparticles holds great promise for clinically translatable diagnostic imaging with high biocompatibility. Metabolically digestible and inherently photoacoustic imaging probes can be developed from nanoprecipitation of biliverdin, a naturally occurring heme-based pigment. The synthesis of nanoparticles composed of a biliverdin network, cross-linked with a bifunctional amine linker, is achieved where spectral tuning relies on the choice of reaction media. Nanoparticles synthesized in water or water containing sodium chloride exhibit higher absorbance and lower fluorescence compared to nanoparticles synthesized in 2-(

Indexed as

Optical ImagingPhotoacoustic TechniquesAnimalsBiliverdineCell Line, TumorCell SurvivalHumansHydrodynamicsLymph NodesMCF-7 CellsMiceMice, NudeNanoparticlesParticle SizeSurface PropertiesSwineBiliverdinebiliverdinbiodegradationbioimagingfluorescentnanoparticlenanoprecipitationphotoacoustic

Identifiers

PMID31246412
PMCPMC6903795

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.