Evidence map›Paper›PMID 31246334›Full record

ArticleMicrocirculation (New York, N.Y. : 1994)2019

Discovery of a bone-like blood particle in the peripheral circulation of humans and rodents.

Rhonda Prisby, Jean Ross, Lynn Opdenaker, Mary Ann McLane, Seungyong Lee, Xiangle Sun, Sophie Guderian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microcirculation (New York, N.Y. : 1994), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rhonda PrisbyDepartment of Kinesiology, University of Texas at Arlington, Arlington, Texas.ORCID 0000-0002-1986-1447
Jean RossDelaware Biotechnology Institute, University of Delaware, Newark, Delaware.
Lynn OpdenakerCenter for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute at Christiana Care Health System, Newark, Delaware.
Mary Ann McLaneDepartment of Medical and Molecular Sciences, University of Delaware, Newark, Delaware.
Seungyong LeeDepartment of Kinesiology, University of Texas at Arlington, Arlington, Texas.
Xiangle SunFlow Cytometry & LCM Core Facility, University of North Texas Health Science Center, Fort Worth, Texas.
Sophie GuderianDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware.

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Anjana Narayan Bhat · 2012 to 2026
$67.2M
Acquisition of a Zeiss LSM710 Confocal MicroscopeS10RR027273 · NCRR · UNIVERSITY OF DELAWARE · PI DUNCAN, MELINDA K · 2010 to 2010
$494k
Bone marrow blood vessel location and blood flow with PTH and anti-VEGFR15AR062882 · NIAMS · UNIVERSITY OF DELAWARE · PI PRISBY, RHONDA · 2012 to 2012
$381k
NCRR NIH HHS S10 RR027273NIAMS NIH HHS R15 AR062882NIGMS NIH HHS P20 GM103446
6 · The paper itself

Abstract

objectiveTo characterize ossified bone marrow blood vessels and confirm the presence of ossified particles (OSP) in humans and rodents.

methodsHuman bone marrow blood vessels were processed for scanning and transmission electron microscopy. Whole blood samples were collected from younger (26-39 years; n = 6) and older (55-63 years; n = 6) volunteers and male Fischer-344 rats (1 month, n = 7; 6 months, n = 7; 12 months, n = 7; 18-months, n = 6; 24 months, n = 8). OSP in the whole blood samples were sorted and imaged with microscopy to determine diameter, circularity, and solidity. Additionally, the chemical composition of OSP was determined via elemental analysis.

resultsSEM revealed two types of ossified bone marrow blood vessels: that is, "transitioning" and "ossified." OSP were adhered to the surface of transitioning vessels and theoretically gain access to and circulate within the blood. The majority of OSP were ≤15 μm in diameter, but many were of sufficient size to serve as emboli (ie, >15 μm).OSP were predominately oblong in shape and several had jagged tips and edges.

conclusionsWe introduce a novel, bone-like blood particle that may be diagnostic of bone marrow blood vessel ossification. Further, OSP may associate with several disease states (eg, atherosclerosis).

Indexed as

Bone MarrowBone Marrow DiseasesExtracellular VesiclesOssification, HeterotopicVascular CalcificationAdultAgedAnimalsFemaleHumansMaleMiddle AgedRatsRats, Inbred F344bone marrow blood vessel ossificationembolihumanossified particlesrat

Identifiers

PMID31246334
PMCPMC6899169

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.