ArticleBehavioral neuroscience2019
Aged rats with intact memory show distinctive recruitment in cortical regions relative to young adults in a cue mismatch task.
Article in Behavioral neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Early Onset Memory Deficit of WMI Rats Compared to Their Nearly Isogenic WLIs Is Reversed by Enriched Environment in Females.Genes, brain, and behavior · 2025Article
- Age-related synaptic signatures of brain and cognitive reserve in the rat hippocampus and parahippocampal regions.Neurobiology of aging · 2025Article
- Assessing cognitive decline in the aging brain: lessons from rodent and human studies.npj aging · 2023Review
- Decreased investigatory head scanning during exploration in learning-impaired, aged rats.Neurobiology of aging · 2021Article
- Significance of inhibitory recruitment in aging with preserved cognition: limiting gamma-aminobutyric acid type A α5 function produces memory impairment.Neurobiology of aging · 2020Article
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Authors and funding
4 authors.
Funding
Abstract
Similar to elderly humans, aged Long-Evans rats exhibit individual differences in performance on tasks that critically depend on the medial temporal lobe memory system. Although reduced memory performance is common, close to half of aged rats in this outbred rodent population perform within the range of young subjects, exhibiting a stable behavioral phenotype that may signal a resilience to memory decline. Increasing evidence from research on aging in the Long-Evans study population supports the existence of adaptive neural change rather than avoidance of detrimental effects of aging on the brain, indicating a malleability of brain function over the life span that may preserve optimal function. Augmenting prior work that centered on hippocampal function, the current study extends investigation to cortical regions functionally interconnected with the hippocampal formation, including medial temporal lobe cortices and posterior components of the default mode network. In response to an environmental manipulation that creates a mismatch in the expected cue orientation, aged rats with preserved memory show greater activation across an extended network of cortical regions as measured by immediate early gene expression. In contrast, young subjects, behaviorally similar to the aged rats in this study, show a more limited cortical response. This distinctive cortical recruitment in aged unimpaired rats, set against a background of comparable activation across hippocampal subregions, may represent adaptive cortical recruitment consistent with evidence in human studies of neurocognitive aging. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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