ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020
Public Health Importance of Invasive Methicillin-sensitive Staphylococcus aureus Infections: Surveillance in 8 US Counties, 2016.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Hospital-Onset Methicillin-Resistant Staphylococcus aureus Prevention in Acute Care Hospitals.JAMA network open · 2026Article
- Trends in methicillin-resistant Staphylococcus aureus detection-rates and antibiotic resistance profiles in a cancer hospital from 2015 to 2024.BMC infectious diseases · 2026Article
- Development and validation of a clinical nomogram for predicting methicillin-resistant Staphylococcus aureus in patients with Staphylococcus aureus bacteremia: a retrospective study.European journal of medical research · 2026Article
- Emergence of a methicillin-susceptibleFrontiers in cellular and infection microbiology · 2026Article
- Fatal Catheter-Related Hematogenous Disseminated MSSA Sepsis in an Immunocompromised Lung Cancer Patient: A Case Report.Infection and drug resistance · 2026Article
- Preclinical evaluation of repositioned non-antibiotic agents against Staphylococcus aureus: a network meta-analysis of survival outcomes.World journal of microbiology & biotechnology · 2025Article
- Review
- The virulence toolkit of Staphylococcus aureus: a comprehensive review of toxin diversity, molecular mechanisms, and clinical implications.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Review
- Participant Diversity in United States Randomized Controlled Trials of Antibacterials for Staphylococcus aureus Infections, 2000-2021.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Genetic and Phenotypic Changes Related to the Development ofAntibiotics (Basel, Switzerland) · 2024Article
- Antimicrobial Resistance Patterns of Outpatient Staphylococcus aureus Isolates.JAMA network open · 2024Article
- Whole-genome sequencing analysis of widely disseminated infection caused by ST2631 methicillin-sensitiveHeliyon · 2024Article
- Quantifying racial disparities in risk of invasiveInfection control and hospital epidemiology · 2024Article
- Different evolution ofHeliyon · 2024Article
- Genomic profiling of methicillin-sensitiveFrontiers in microbiology · 2024Article
- Determining the Prognostic Value of Complete Blood Count Subgroup Parameters inJournal of patient-centered research and reviews · 2024Article
- Clonal Diversity, Antibiotic Resistance, and Virulence Factor Prevalence of Community AssociatedPathogens (Basel, Switzerland) · 2023Article
- Genomic epidemiology ofMicrobial genomics · 2023Observational
- Prevalence and Characterization of the Cefazolin Inoculum Effect in North American Methicillin-Susceptible Staphylococcus aureus Isolates.Journal of clinical microbiology · 2022Article
- A Case of Methicillin-Sensitive Staphylococcus aureus (MSSA) Prostate Abscess, Osteomyelitis, and Myositis Associated with MSSA Bacteremia in a 60-Year-Old Patient Presenting with Back Pain.The American journal of case reports · 2022Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundPublic health and infection control prevention and surveillance efforts in the United States have primarily focused on methicillin-resistant Staphylococcus aureus (MRSA). We describe the public health importance of methicillin-susceptible S. aureus (MSSA) in selected communities.
methodsWe analyzed Emerging Infections Program surveillance data for invasive S. aureus (SA) infections (isolated from a normally sterile body site) in 8 counties in 5 states during 2016. Cases were considered healthcare-associated if culture was obtained >3 days after hospital admission; if associated with dialysis, hospitalization, surgery, or long-term care facility (LTCF) residence within 1 year prior; or if a central venous catheter was present ≤2 days prior. Incidence per 100 000 census population was calculated, and a multivariate logistic regression model with random intercepts was used to compare MSSA risk factors with those of MRSA.
resultsInvasive MSSA incidence (31.3/100 000) was 1.8 times higher than MRSA (17.5/100 000). Persons with MSSA were more likely than those with MRSA to have no underlying medical conditions (adjusted odds ratio [aOR], 2.06; 95% confidence interval [CI], 1.26-3.39) and less likely to have prior hospitalization (aOR, 0.70; 95% CI, 0.60-0.82) or LTCF residence (aOR, 0.37; 95% CI, 0.29-0.47). MSSA accounted for 59.7% of healthcare-associated cases and 60.1% of deaths.
conclusionsAlthough MRSA tended to be more closely associated with healthcare exposures, invasive MSSA is a substantial public health problem in the areas studied. Public health and infection control prevention efforts should consider MSSA prevention in addition to MRSA.
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