Evidence map›Paper›PMID 31245628›Full record

ArticleJournal of psychiatry and brain science2019

GAD mRNA in Orbital Prefrontal Cortex and Anterior Cingulate Cortex in Alcoholics Compared with Nonpsychiatric Controls: A Negative Postmortem Study.

Mark D Underwood, Mihran J Bakalian, Andrew J Dwork, Eli Min, J John Mann, Victoria Arango

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry and brain science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Impairment of the GABAergic system in the prefrontal cortex of male heroin addicts.European archives of psychiatry and clinical neuroscience · 2026
    Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Mark D UnderwoodDepartment of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY 10032, USA.
Mihran J BakalianDepartment of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY 10032, USA.
Andrew J DworkDepartment of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY 10032, USA.
Eli MinDepartment of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY 10032, USA.
J John MannDepartment of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY 10032, USA.
Victoria ArangoDepartment of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY 10032, USA.
New York Psychoanalytic Society and Institute · USColumbia University · USNew York State Psychiatric Institute

Funding

THE NEUROBIOLOGY OF SUICIDAL BEHAVIORP50MH062185 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MANN, JOSEPH JOHN · 2000 to 2009
$21.7M
POSTMORTEM NEUROCHEMICAL STUDIES IN SUICIDER01MH040210 · NIMH · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI UNDERWOOD, MARK D · 1985 to 2016
$7.0M
Golgi Studies of SchizophreniaR01MH064168 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI DWORK, ANDREW J · 2001 to 2013
$4.3M
DORSAL RAPHE NUCLEUS SEROTONIN NEURONS IN ALCOHOLISMR01AA011293 · NIAAA · NEW YORK STATE PSYCHIATRIC INSTITUTE · PI UNDERWOOD, MARK D · 1997 to 2012
$3.7M
Building Schizophrenia Research in MacedoniaR01MH098786 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DWORK, ANDREW J, ROSOKLIJA, GORAZD B. · 2012 to 2016
$2.2M
NIAAA NIH HHS R01 AA011293NIMH NIH HHS P50 MH062185NIMH NIH HHS R01 MH040210NIMH NIH HHS R01 MH064168NIMH NIH HHS R01 MH098786
6 · The paper itself

Abstract

Alcohol increases inhibitory neurotransmission, an effect mediated through GABA receptors. With chronic alcohol exposure, the inhibitory effects diminish. Glutamic acid decarboxylase (GAD) catalyzes glutamate in the synthesis of GABA. We sought to determine the amount of GAD

Indexed as

alcoholGABAhumanin situ hybridizationpostmortem

Identifiers

PMID31245628
PMCPMC6594560
OpenAlexW2944352047

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.