Evidence map›Paper›PMID 31245500›Full record

ArticleRegenerative therapy2016

Generating tissue-engineered intestinal epithelium from cultured Lgr5 stem cells

Zhassulan Baimakhanov, Yasuhiro Torashima, Akihiko Soyama, Yusuke Inoue, Yusuke Sakai, Mitsuhisa Takatsuki, Fumihiko Fujita, Kengo Kanetaka, Tamotsu Kuroki, Susumu Eguchi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Zhassulan BaimakhanovDepartment of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Yasuhiro TorashimaDepartment of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Akihiko SoyamaDepartment of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Yusuke InoueDepartment of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Yusuke SakaiDepartment of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Mitsuhisa TakatsukiDepartment of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Fumihiko FujitaDepartment of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Kengo KanetakaDepartment of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Tamotsu KurokiDepartment of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Susumu EguchiDepartment of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Nagasaki University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGenerating tissue-engineered small intestine (TESI) from mature intestinal cells has been established in a mouse model. The purpose of this study was to generate TESI from Lgr5 stem cells

methodsWe used Lgr5-EGFP mice for intestinal crypt isolation. After seven days, cultured crypts with Lgr5 stem cells were seeded onto a biodegradable polymer and implanted into omentum of NOD/SCID mice.

resultsEngineered intestinal epithelium was generated from Lgr5 stem cells after four weeks of

conclusionOur observations suggest that transplanted Lgr5 stem cells can differentiate into the intestinal epithelium

Indexed as

CryptEngineered small intestineIntestinal epitheliumLgr5 cellsPAS, periodic acid-Schiff stainingTESI, tissue-engineered small intestine

Identifiers

PMID31245500
PMCPMC6581835
OpenAlexW2511938615

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.