Evidence map›Paper›PMID 31245495›Full record

ArticleRegenerative therapy2016

Antagomir-92a impregnated gelatin hydrogel microsphere sheet enhances cardiac regeneration after myocardial infarction in rats.

Masanori Fujita, Hajime Otani, Masayoshi Iwasaki, Kei Yoshioka, Takayuki Shimazu, Ichiro Shiojima, Yasuhiko Tabata

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Article in Regenerative therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Masanori FujitaDepartment of Medicine II, Kansai Medical University, Moriguchi City, Japan.
Hajime OtaniDepartment of Medicine II, Kansai Medical University, Moriguchi City, Japan.
Masayoshi IwasakiDepartment of Medicine II, Kansai Medical University, Moriguchi City, Japan.
Kei YoshiokaDepartment of Medicine II, Kansai Medical University, Moriguchi City, Japan.
Takayuki ShimazuDepartment of Medicine II, Kansai Medical University, Moriguchi City, Japan.
Ichiro ShiojimaDepartment of Medicine II, Kansai Medical University, Moriguchi City, Japan.
Yasuhiko TabataDepartment of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Kyoto City, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe investigated whether attachment of gelatin hydrogel microsphere (GHM) sheet impregnated with antagomir-92a on the infarcted heart promotes angiogenesis and cardiomyogenesis, and improves cardiac function after myocardial infarction (MI) in rats.

methodsGHM sheet impregnated with antagomir-92a, its scramble sequence antagomir-control sheet or the sheet alone was attached on the area at risk of MI after the left anterior descending coronary artery ligation. Bromodeoxyuridine (BrdU) was included in the sheet to trace proliferating cells.

resultsThe antagomir-92a sheet significantly increased capillary density in the infarct border zone 14 days after MI compared to the antagomir-control sheet or the sheet alone, associated with an increase in endothelial cells incorporated with BrdU. The antagomir-92a sheet significantly increased cardiac stem cells incorporated with BrdU 3 days after MI in the infarct border zone. This was associated with an increase in cardiomyocytes incorporated with BrdU 14 days after MI. Scar area was significantly reduced by the antagomir-92a sheet compared to the antagomir-control sheet or the sheet alone (12.8 ± 1.3 vs 25.2 ± 2.2, 24.0 ± 1.7% LV area, respectively) 14 days after MI. LV dilatation was inhibited, and LV wall motion was improved 14 days after MI in rats with the antagomir-92a sheet compared to the antagomir-control sheet or the sheet alone.

conclusionsThese results suggest that attachment of the GHM sheet impregnated with antagomir-92a on the area at risk of MI enhances angiogenesis, promotes cardiomyogenesis, and ameliorates LV function.

Indexed as

AngiogenesisBrdU, bromodeoxyuridineDAPI, 4′,6-diamidino-2-phenylindoleDDA, double-distilled waterFGF, fibroblast growth factorFS, fractional shorteningGA, glutaraldehydeGelatin hydrogel microsphereGHM, gelatin hydrogel microsphereHeart regenerationLAD, left anterior descendingLVDd, left ventricular end-diastolic diameterLVDs, left ventricular end-systolic diameterLV, left ventricularMicroRNA-92aMI, myocardial infarctionmiRs, microRNAsMSCs, mesenchymal stem cellsVEGF, vascular endothelial growth factor

Identifiers

PMID31245495
PMCPMC6581790

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.