Evidence map›Paper›PMID 31245479›Full record

ArticleRegenerative therapy2016

A heparin-modified thermoresponsive surface with heparin-binding epidermal growth factor-like growth factor for maintaining hepatic functions

Yoshinori Arisaka, Jun Kobayashi, Kazuo Ohashi, Kohei Tatsumi, Kyungsook Kim, Yoshikatsu Akiyama, Masayuki Yamato, Teruo Okano

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Molecular design of dynamically thermoresponsive biomaterials.Science and technology of advanced materials · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yoshinori ArisakaInstitute of Advanced Biomedical Engineering and Science and Global Center of Excellence (COE) Program, Tokyo Women's Medical University (TWIns), 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan.
Jun KobayashiInstitute of Advanced Biomedical Engineering and Science and Global Center of Excellence (COE) Program, Tokyo Women's Medical University (TWIns), 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan.
Kazuo OhashiInstitute of Advanced Biomedical Engineering and Science and Global Center of Excellence (COE) Program, Tokyo Women's Medical University (TWIns), 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan.
Kohei TatsumiInstitute of Advanced Biomedical Engineering and Science and Global Center of Excellence (COE) Program, Tokyo Women's Medical University (TWIns), 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan.
Kyungsook KimInstitute of Advanced Biomedical Engineering and Science and Global Center of Excellence (COE) Program, Tokyo Women's Medical University (TWIns), 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan.
Yoshikatsu AkiyamaInstitute of Advanced Biomedical Engineering and Science and Global Center of Excellence (COE) Program, Tokyo Women's Medical University (TWIns), 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan.
Masayuki YamatoInstitute of Advanced Biomedical Engineering and Science and Global Center of Excellence (COE) Program, Tokyo Women's Medical University (TWIns), 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan.
Teruo OkanoInstitute of Advanced Biomedical Engineering and Science and Global Center of Excellence (COE) Program, Tokyo Women's Medical University (TWIns), 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan.
Tokyo Women's Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A heparin-modified thermoresponsive surface bound with heparin-binding epidermal growth factor-like growth factor (HB-EGF) was designed to allow creation of transferrable and functional hepatocyte sheets. A heparin-modified thermoresponsive surface was prepared by covalently tethering heparin onto poly(

Indexed as

Alb, albuminbFGF, basic fibroblast growth factorCIPAAm, 2-carboxyisopropylacrylamideDMEM, Dulbecco's modified Eagle's mediumECM, extracellular matrixEDC, 1-ethyl-3-(3-dimetylaminopropyl)-carbodiimide hydrochlorideEDTA, trypsin/ethylenediaminetetraacetic acidEGF, epidermal growth factorELISA, enzyme-linked immunosorbent assayF7, coagulation factor VIIF9, coagulation factor IXFBS, fetal bovine serumHB-EGF, heparin-binding EGF-like growth factorHB-EGFX/heparin-IC, HB-EGF-bound heparin-ICHeparinHeparin-binding EGF-like growth factorheparin-IC, heparin-modified ICHepatocyte sheetHnf4α, hepatocyte nuclear factor 4 alphaIC, poly(N-isopropylacrylamide-co-2-carboxyisopropylacrylamide) on TCPSIPAAm, N-isopropylacrylamideMES, morpholinoethanesulfonic acid monohydrateNHS, N-hydroxysuccinimidePBS, Dulbecco's phosphate buffered salinePIPAAm + HB-EGFY, PIPAAm with soluble HB-EGFPIPAAm, poly(N-isopropylacrylamide) on TCPSPoly(N-isopropylacrylamide)RT-PCR, reverse transcription polymerase chain reactionTCPS, tissue culture polystyrene disheThermoresponsive cell culture surface

Identifiers

PMID31245479
PMCPMC6581876
OpenAlexW2319364912

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.