Evidence map›Paper›PMID 31245369›Full record

ArticleFrontiers in cell and developmental biology2019

Rewiring the Regenerated Zebrafish Retina: Reemergence of Bipolar Neurons and Cone-Bipolar Circuitry Following an Inner Retinal Lesion.

Timothy E McGinn, Carlos A Galicia, Dylan C Leoni, Natalie Partington, Diana M Mitchell, Deborah L Stenkamp

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. The Healthy and Diseased Retina Seen through Neuron-Glia Interactions.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
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  10. Retinal regeneration requires dynamic Notch signaling.Neural regeneration research · 2022
    Review
  11. Review
  12. Article
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Timothy E McGinnDepartment of Biological Sciences, University of Idaho, Moscow, ID, United States.
Carlos A GaliciaDepartment of Biological Sciences, University of Idaho, Moscow, ID, United States.
Dylan C LeoniDepartment of Biological Sciences, University of Idaho, Moscow, ID, United States.
Natalie PartingtonDepartment of Biology, Brigham Young University-Idaho, Rexburg, ID, United States.
Diana M MitchellDepartment of Biological Sciences, University of Idaho, Moscow, ID, United States.
Deborah L StenkampDepartment of Biological Sciences, University of Idaho, Moscow, ID, United States.
University of Idaho · USBrigham Young University - Idaho · US

Funding

Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote WestP20GM103408 · NIGMS · UNIVERSITY OF IDAHO · PI Scott A Minnich · 2012 to 2026
$59.8M
Acquisition of a Dynamic Imaging SystemS10OD018044 · OD · UNIVERSITY OF IDAHO · PI STENKAMP, DEBORAH L · 2014 to 2014
$455k
Synapses in Regenerated RetinaR21EY026814 · NEI · UNIVERSITY OF IDAHO · PI STENKAMP, DEBORAH L · 2016 to 2017
$388k
NEI NIH HHS R21 EY026814NIGMS NIH HHS P20 GM103408NIH HHS S10 OD018044
6 · The paper itself

Abstract

We previously reported strikingly normal morphologies and functional connectivities of regenerated retinal bipolar neurons (BPs) in zebrafish retinas sampled 60 days after a ouabain-mediated lesion of inner retinal neurons (60 DPI) (McGinn et al., 2018). Here we report early steps in the birth of BPs and formation of their dendritic trees and axonal arbors during regeneration. Adult zebrafish were subjected to ouabain-mediated lesion that destroys inner retinal neurons but spares photoreceptors and Müller glia, and were sampled at 13, 17, and 21 DPI, a timeframe over which plexiform layers reemerge. We show that this timeframe corresponds to reemergence of two populations of BPs (PKCα+ and

Indexed as

birthdatingcircuitryconnectomephotoreceptorregenerationretinaretinal bipolar cellzebrafish

Identifiers

PMID31245369
PMCPMC6562337
OpenAlexW2949046907

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.