Evidence map›Paper›PMID 31245298›Full record

ArticleFrontiers in cellular and infection microbiology2019

Multi-platform Approach for Microbial Biomarker Identification Using

Kathryn J Pflughoeft, Michael Mash, Nicole R Hasenkampf, Mary B Jacobs, Amanda C Tardo, D Mitchell Magee, Lusheng Song, Joshua LaBaer, Mario T Philipp, Monica E Embers and 1 more

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kathryn J PflughoeftDxDiscovery, Inc., Reno, NV, United States.
Michael MashDxDiscovery, Inc., Reno, NV, United States.
Nicole R HasenkampfDivision of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA, United States.
Mary B JacobsDivision of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA, United States.
Amanda C TardoDivision of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA, United States.
D Mitchell MageeCenter for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, United States.
Lusheng SongCenter for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, United States.
Joshua LaBaerCenter for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, United States.
Mario T PhilippDivision of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA, United States.
Monica E EmbersDivision of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA, United States.
David P AuCoinDxDiscovery, Inc., Reno, NV, United States.

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
Outreach/Diversity/Pipeline ProjectP20GM103440 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Julia Petereit · 2012 to 2026
$58.0M
Identification of Borrelia burgdorferi diagnostic biomarkers in humans and nonhumR41AI114049 · NIAID · DXDISCOVERY, INC. · PI AUCOIN, DAVID P, EMBERS, MONICA E · 2014 to 2015
$592k
NIAID NIH HHS R41 AI114049NIGMS NIH HHS P20 GM103440NIH HHS P51 OD011104
6 · The paper itself

Abstract

The identification of microbial biomarkers is critical for the diagnosis of a disease early during infection. However, the identification of reliable biomarkers is often hampered by a low concentration of microbes or biomarkers within host fluids or tissues. We have outlined a multi-platform strategy to assess microbial biomarkers that can be consistently detected in host samples, using

Indexed as

BiomarkersAnimalsAntibodies, BacterialAntigens, BacterialBacteriological TechniquesBorrelia burgdorferiEarly DiagnosisHumansLyme DiseaseMacaca mulattaProteomicsSerumUrineAntibodies, BacterialAntigens, BacterialBiomarkersantibody responseBorrelia burgdorferiearly diagnosticLyme diseasemicrobial biomarker discovery

Identifiers

PMID31245298
PMCPMC6579940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.