Evidence map›Paper›PMID 31244934›Full record

ArticleTheranostics2019

Highly sensitive quantification of Alzheimer's disease biomarkers by aptamer-assisted amplification.

Hei-Nga Chan, Di Xu, See-Lok Ho, Dinggeng He, Man Shing Wong, Hung-Wing Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hei-Nga ChanDepartment of Chemistry, Hong Kong Baptist University, Hong Kong, China.
Di XuDepartment of Chemistry, Hong Kong Baptist University, Hong Kong, China.
See-Lok HoDepartment of Chemistry, Hong Kong Baptist University, Hong Kong, China.
Dinggeng HeDepartment of Chemistry, Hong Kong Baptist University, Hong Kong, China.
Man Shing WongDepartment of Chemistry, Hong Kong Baptist University, Hong Kong, China.
Hung-Wing LiDepartment of Chemistry, Hong Kong Baptist University, Hong Kong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD), a chronic neurodegenerative disease associated with the loss of neurons in the brain, is the most pervasive type of dementia; 47 million people are affected, and the number is expected to increase to more than 131 million by 2050, according to Alzheimer's Disease International. Both early diagnosis and continuous monitoring are crucial for early intervention, symptomatic treatment, monitoring of the efficacy of intervention and improved patient function. Beta-amyloid peptide, tau, and phosphorylated tau are useful for screening and diagnosis; meanwhile, simultaneous assessment of multiple biomarkers is of paramount importance for accurate disease diagnosis.

Indexed as

Nucleic Acid Amplification TechniquesAlzheimer DiseaseAmyloid beta-PeptidesAptamers, NucleotideBiomarkersHumansImmunoglobulinsSensitivity and SpecificityAmyloid beta-PeptidesAptamers, NucleotideBiomarkersImmunoglobulinsAlzheimer's diseaseantibody-aptamer hybrid immunoassaymagnetic nanoparticleturn-on fluorophore

Identifiers

PMID31244934
PMCPMC6568170

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.