Evidence map›Paper›PMID 31244895›Full record

ReviewTherapeutic advances in gastroenterology2019

Pathophysiology and management of diabetic gastroenteropathy.

Theresa Meldgaard, Jutta Keller, Anne Estrup Olesen, Søren Schou Olesen, Klaus Krogh, Mette Borre, Adam Farmer, Birgitte Brock, Christina Brock, Asbjørn Mohr Drewes

Open access · goldAbstract readReview
In one paragraph

Review in Therapeutic advances in gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Guideline
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  6. Autonomic neuropathy in diabetes.Archives of endocrinology and metabolism · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Theresa MeldgaardMech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Denmark.
Jutta KellerIsraelitic Hospital in Hamburg, Academic Hospital University of Hamburg, Germany.
Anne Estrup OlesenMech-Sense, Department of Gastroenterology and Hepatology and Department of Clinical Medicine, Aalborg University Hospital, Denmark.
Søren Schou OlesenMech-Sense, Department of Gastroenterology and Hepatology and Department of Clinical Medicine, Aalborg University Hospital, Denmark.
Klaus KroghDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Denmark.
Mette BorreDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Denmark.
Adam FarmerDepartment of Gastroenterology, University Hospitals of North Midlands, Stoke on Trent, Staffordshire, UK.
Birgitte BrockDepartment of Clinical Research, Steno Diabetes Center Copenhagen (SDCC), Denmark.
Christina BrockMech-Sense, Department of Gastroenterology and Hepatology and Department of Clinical Medicine, Aalborg University Hospital, Denmark.
Asbjørn Mohr DrewesMech-Sense, Department of Gastroenterology and Hepatology and Department of Clinical Medicine, Aalborg University Hospital, Denmark.ORCID https://orcid.org/0000-0002-8833-1984
Aalborg University Hospital · DKAarhus University Hospital · DKQueen Mary University of London · GBSteno Diabetes Centers · DKUniversität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyneuropathy is a common complication to diabetes. Neuropathies within the enteric nervous system are associated with gastroenteropathy and marked symptoms that severely reduce quality of life. Symptoms are pleomorphic but include nausea, vomiting, dysphagia, dyspepsia, pain, bloating, diarrhoea, constipation and faecal incontinence. The aims of this review are fourfold. First, to provide a summary of the pathophysiology underlying diabetic gastroenteropathy. Secondly to give an overview of the diagnostic methods. Thirdly, to provide clinicians with a focussed overview of current and future methods for pharmacological and nonpharmacological treatment modalities. Pharmacological management is categorised according to symptoms arising from the upper or lower gut as well as sensory dysfunctions. Dietary management is central to improvement of symptoms and is discussed in detail, and neuromodulatory treatment modalities and other emerging management strategies for diabetic gastroenteropathy are discussed. Finally, we propose a diagnostic/investigation algorithm that can be used to support multidisciplinary management.

Indexed as

complicationsdiabetes mellitusdiabetic neuropathiesenteric nervous systementeropathygastrointestinal motilitygastrointestinal transitpharmacology

Identifiers

PMID31244895
PMCPMC6580709
OpenAlexW2950077332

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.