Evidence map›Paper›PMID 31244869›Full record

ArticleFrontiers in plant science2019

Production of Biopharmaceuticals in

Marie-Claire Goulet, Linda Gaudreau, Marielle Gagné, Anne-Marie Maltais, Ann-Catherine Laliberté, Gilbert Éthier, Nicole Bechtold, Michèle Martel, Marc-André D'Aoust, André Gosselin and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in plant science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. The biosynthesis of trillin 6'-Synthetic and systems biotechnology · 2025
    Article
  9. Article
  10. Article
  11. Molecular Farming of Pembrolizumab and Nivolumab.International journal of molecular sciences · 2023
    Review
  12. A Review of Virus-Like Particle-Based SARS-CoV-2 Vaccines in Clinical Trial Phases.Iranian journal of pharmaceutical research : IJPR · 2022
    Review
  13. Article
  14. Effect of the At-CDC27a gene onFrontiers in plant science · 2022
    Article
  15. Transient proteolysis reduction ofFrontiers in plant science · 2022
    Article
  16. Article
  17. Review
  18. Frontiers in plant science · 2021
    Article
  19. Plant Platforms for Efficient Heterologous Protein Production.Biotechnology and bioprocess engineering : BBE · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Marie-Claire GouletCentre de recherche et d'innovation sur les végétaux, Faculté des Sciences de l'agriculture et de l'alimentation, Université Laval, Québec, QC, Canada.
Linda GaudreauCentre de recherche et d'innovation sur les végétaux, Faculté des Sciences de l'agriculture et de l'alimentation, Université Laval, Québec, QC, Canada.
Marielle GagnéCentre de recherche et d'innovation sur les végétaux, Faculté des Sciences de l'agriculture et de l'alimentation, Université Laval, Québec, QC, Canada.
Anne-Marie MaltaisCentre de recherche et d'innovation sur les végétaux, Faculté des Sciences de l'agriculture et de l'alimentation, Université Laval, Québec, QC, Canada.
Ann-Catherine LalibertéCentre de recherche et d'innovation sur les végétaux, Faculté des Sciences de l'agriculture et de l'alimentation, Université Laval, Québec, QC, Canada.
Gilbert ÉthierCentre de recherche et d'innovation sur les végétaux, Faculté des Sciences de l'agriculture et de l'alimentation, Université Laval, Québec, QC, Canada.
Nicole BechtoldMedicago Inc., Québec, QC, Canada.
Michèle MartelMedicago Inc., Québec, QC, Canada.
Marc-André D'AoustMedicago Inc., Québec, QC, Canada.
André GosselinCentre de recherche et d'innovation sur les végétaux, Faculté des Sciences de l'agriculture et de l'alimentation, Université Laval, Québec, QC, Canada.
Steeve PepinCentre de recherche et d'innovation sur les végétaux, Faculté des Sciences de l'agriculture et de l'alimentation, Université Laval, Québec, QC, Canada.
Dominique MichaudCentre de recherche et d'innovation sur les végétaux, Faculté des Sciences de l'agriculture et de l'alimentation, Université Laval, Québec, QC, Canada.
Université Laval · CAMedicago (Canada) · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Data are scarce about the influence of basic cultural conditions on growth patterns and overall performance of plants used as heterologous production hosts for protein pharmaceuticals. Higher plants are complex organisms with young, mature, and senescing organs that show distinct metabolic backgrounds and differ in their ability to sustain foreign protein expression and accumulation. Here, we used the transient protein expression host

Indexed as

6-benzylaminopurineapical pruninghormone treatmentinfluenza virus hemagglutinin H1light regimeNicotiana benthamianaplant molecular farming

Identifiers

PMID31244869
PMCPMC6579815
OpenAlexW2952796400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.