Evidence map›Paper›PMID 31244866›Full record

ReviewFrontiers in plant science2019

Alternative Splicing and Protein Diversity: Plants Versus Animals.

Saurabh Chaudhary, Waqas Khokhar, Ibtissam Jabre, Anireddy S N Reddy, Lee J Byrne, Cornelia M Wilson, Naeem H Syed

Abstract readReview
In one paragraph

Review in Frontiers in plant science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. bioRxiv : the preprint server for biology · 2025
    Article
  6. Impact of alternative splicing on Arabidopsis proteome.bioRxiv : the preprint server for biology · 2025
    Article
  7. Review
  8. Genome-Wide Isoform Switching Reveals SR45-Mediated Splicing Control ofInternational journal of molecular sciences · 2025
    Article
  9. Article
  10. RNA-binding proteins orchestrating immunity in plants.The Plant journal : for cell and molecular biology · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. DecodingbioRxiv : the preprint server for biology · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Saurabh ChaudharySchool of Human and Life Sciences, Canterbury Christ Church University, Canterbury, United Kingdom.
Waqas KhokharSchool of Human and Life Sciences, Canterbury Christ Church University, Canterbury, United Kingdom.
Ibtissam JabreSchool of Human and Life Sciences, Canterbury Christ Church University, Canterbury, United Kingdom.
Anireddy S N ReddyDepartment of Biology and Program in Cell and Molecular Biology, Colorado State University, Fort Collins, CO, United States.
Lee J ByrneSchool of Human and Life Sciences, Canterbury Christ Church University, Canterbury, United Kingdom.
Cornelia M WilsonSchool of Human and Life Sciences, Canterbury Christ Church University, Canterbury, United Kingdom.
Naeem H SyedSchool of Human and Life Sciences, Canterbury Christ Church University, Canterbury, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plants, unlike animals, exhibit a very high degree of plasticity in their growth and development and employ diverse strategies to cope with the variations during diurnal cycles and stressful conditions. Plants and animals, despite their remarkable morphological and physiological differences, share many basic cellular processes and regulatory mechanisms. Alternative splicing (AS) is one such gene regulatory mechanism that modulates gene expression in multiple ways. It is now well established that AS is prevalent in all multicellular eukaryotes including plants and humans. Emerging evidence indicates that in plants, as in animals, transcription and splicing are coupled. Here, we reviewed recent evidence in support of co-transcriptional splicing in plants and highlighted similarities and differences between plants and humans. An unsettled question in the field of AS is the extent to which splice isoforms contribute to protein diversity. To take a critical look at this question, we presented a comprehensive summary of the current status of research in this area in both plants and humans, discussed limitations with the currently used approaches and suggested improvements to current methods and alternative approaches. We end with a discussion on the potential role of epigenetic modifications and chromatin state in splicing memory in plants primed with stresses.

Indexed as

alternative splicingco-transcriptional splicingepigenetic modificationsintron retentionNMDprotein diversitysplicing memory

Identifiers

PMID31244866
PMCPMC6581706

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.