Evidence map›Paper›PMID 31244845›Full record

ReviewFrontiers in immunology2019

Ikaros Zinc Finger Transcription Factors: Regulators of Cytokine Signaling Pathways and CD4

Michael D Powell, Kaitlin A Read, Bharath K Sreekumar, Kenneth J Oestreich

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 105 citations in OpenAlex.

  1. Article
  2. CNS1-dependent regulatory T cells shape recovery from acute lung injury.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Article
  3. Aiolos and Eos drive distinct human TH17 functional states.Cellular and molecular life sciences : CMLS · 2026
    Article
  4. Article
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  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. DEFA5-producing CD4Frontiers in immunology · 2025
    Article
  19. Review
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Michael D PowellFralin Biomedical Research Institute, Virginia Tech Carilion, Roanoke, VA, United States.
Kaitlin A ReadFralin Biomedical Research Institute, Virginia Tech Carilion, Roanoke, VA, United States.
Bharath K SreekumarFralin Biomedical Research Institute, Virginia Tech Carilion, Roanoke, VA, United States.
Kenneth J OestreichFralin Biomedical Research Institute, Virginia Tech Carilion, Roanoke, VA, United States.
Biomedical Research Institute · USVirginia–Maryland College of Veterinary Medicine · US

Funding

Identifying novel regulatory pathways underlying T helper 1 cell immune responsesR01AI134972 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI OESTREICH, KENNETH JOSEPH · 2018 to 2022
$1.9M
NIAID NIH HHS R01 AI134972
6 · The paper itself

Abstract

CD4

Indexed as

ImmunomodulationSignal TransductionZinc FingersAnimalsCD4-Positive T-LymphocytesCell DifferentiationCytokinesHumansIkaros Transcription FactorSTAT Transcription FactorsT-Lymphocyte SubsetsCytokinesIkaros Transcription FactorSTAT Transcription FactorsCD4+ T helper cellscytokinesdifferentiationgene regulationIkaros zinc finger (IkZF) transcription factors

Identifiers

PMID31244845
PMCPMC6563078
OpenAlexW2967117221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.