Evidence map›Paper›PMID 31244842›Full record

Trial reportFrontiers in immunology2019

Flagellin/NLRC4 Pathway Rescues NLRP3-Inflammasome Defect in Dendritic Cells From HIV-Infected Patients: Perspective for New Adjuvant in Immunocompromised Individuals.

Edione Cristina Dos Reis, Vinícius Nunes Cordeiro Leal, Jaíne Lima da Silva Soares, Fernanda Pereira Fernandes, Dhêmerson Souza de Lima, Bruna Cunha de Alencar, Alessandra Pontillo

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 41 citations in OpenAlex.

  1. The recent advances in vaccine adjuvants.Frontiers in immunology · 2025
    Review
  2. Article
  3. Article
  4. NLRP3 Inflammasomes: Dual Function in Infectious Diseases.Journal of immunology (Baltimore, Md. : 1950) · 2024
    Review
  5. Review
  6. Article
  7. Inflammasomes as mediators of inflammation in HIV-1 infection.Translational research : the journal of laboratory and clinical medicine · 2023
    Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Exploration of Pattern Recognition Receptor Agonists as Candidate Adjuvants.Frontiers in cellular and infection microbiology · 2021
    Review
  13. Computational and mathematical methods in medicine · 2021
    Article
  14. The Role of Flagellin B inFrontiers in immunology · 2021
    Article
  15. Review
  16. Review
  17. Article
  18. Inflammasomes as Targets for Adjuvants.Pathogens (Basel, Switzerland) · 2020
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Edione Cristina Dos ReisLaboratory of Immunogenetics, Department of Immunology, Institute of Biomedical Sciences/ICB, University of São Paulo/USP, São Paulo, Brazil.
Vinícius Nunes Cordeiro LealLaboratory of Immunogenetics, Department of Immunology, Institute of Biomedical Sciences/ICB, University of São Paulo/USP, São Paulo, Brazil.
Jaíne Lima da Silva SoaresLaboratory of Immunogenetics, Department of Immunology, Institute of Biomedical Sciences/ICB, University of São Paulo/USP, São Paulo, Brazil.
Fernanda Pereira FernandesLaboratory of Immunogenetics, Department of Immunology, Institute of Biomedical Sciences/ICB, University of São Paulo/USP, São Paulo, Brazil.
Dhêmerson Souza de LimaLaboratory of Immunogenetics, Department of Immunology, Institute of Biomedical Sciences/ICB, University of São Paulo/USP, São Paulo, Brazil.
Bruna Cunha de AlencarLaboratory of Immune System Cell Biology, Department of Immunology, Institute of Biomedical Sciences/ICB, University of São Paulo/USP, São Paulo, Brazil.
Alessandra PontilloLaboratory of Immunogenetics, Department of Immunology, Institute of Biomedical Sciences/ICB, University of São Paulo/USP, São Paulo, Brazil.
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adjuvants, ImmunologicAdultCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsDendritic CellsFemaleFilaggrin ProteinsFlagellinHIV-1HIV InfectionsHumansImmunocompromised HostInflammasomesMaleMiddle AgedNLR Family, Pyrin Domain-Containing 3 ProteinAdjuvants, ImmunologicCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsFilaggrin ProteinsFlagellinFLG protein, humanInflammasomesNLRC4 protein, humanNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanadjuvantdendritic cellflagellinHIVinflammasomeNLRC4

Identifiers

PMID31244842
PMCPMC6579915
OpenAlexW2950595586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.