Evidence map›Paper›PMID 31244822›Full record

ArticleFrontiers in immunology2019

Identification and

Theresa Enkirch, Svenja Sauber, Danielle E Anderson, Esther S Gan, Dimitar Kenanov, Sebastian Maurer-Stroh, Veronika von Messling

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Metallo-antiviral aspirants:European journal of medicinal chemistry reports · 2023
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Measles Resurgence and Drug Development.Current opinion in virology · 2020
    Review
  10. Gallium maltolate hasAntiviral chemistry & chemotherapy
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Theresa EnkirchProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Svenja SauberVeterinary Medicine Division, Paul-Ehrlich-Institut, Langen, Germany.
Danielle E AndersonProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Esther S GanProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Dimitar KenanovBiomolecular Function Discovery Division, Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore.
Sebastian Maurer-StrohBiomolecular Function Discovery Division, Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore.
Veronika von MesslingProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Paul Ehrlich Institut · DEDuke-NUS Medical School · SGAgency for Science, Technology and Research · SGBioinformatics Institute · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The high genetic variability of influenza A viruses poses a continual challenge to seasonal and pandemic vaccine development, leaving antiviral drugs as the first line of defense against antigenically different strains or new subtypes. As resistance against drugs targeting viral proteins emerges rapidly, we assessed the antiviral activity of already approved drugs that target cellular proteins involved in the viral life cycle and were orally bioavailable. Out of 15 candidate compounds, four were able to inhibit infection by 10- to 100-fold without causing toxicity,

Indexed as

Antiviral AgentsComputational BiologyAdministration, OralAnimalsDogsFerretsHumansInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza, HumanMadin Darby Canine Kidney CellsMiceAntiviral Agentsanimal modelsantiviral (H1N1 and H3N2) activitydrug repurposinghost protein-targeting drugsinfluenza A virus

Identifiers

PMID31244822
PMCPMC6563844
OpenAlexW2949033011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.