ArticleFrontiers in physiology2019
Physical Exercise as Personalized Medicine for Dementia Prevention?
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- The Effects of Exercise on BDNF Levels in Adolescents: A Systematic Review with Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Nonlinear Gait Variability and the Role of Cognitive-Physical Exercise in Mitigating Mobility Decline in Institutionalized Older Adults with Cognitive Impairment.Journal of functional morphology and kinesiology · 2026Article
- Physical activity and exercise in dementia: clinical relevance and emerging insights.Frontiers in dementia · 2026Review
- Promoting Physical Activity and Preventing Falls Among Older Adults in a Nursing Home Setting: Protocol for Development and Implementation of the BeSt Age Mobile App.JMIR research protocols · 2025Article
- Association between Multi-Domain Lifestyle and Objective Cognitive Impairment in Elderly People with SCD and MCI in Chinese Communities.Healthcare (Basel, Switzerland) · 2024Article
- Effects of Cognitively Stimulating Activities on the Cognitive Functioning of Older People with Mild Cognitive Impairment: A Meta-analysis.Acta medica Philippina · 2024Article
- Factors Affecting Physical Activity in People with Dementia: A Systematic Review and Narrative Synthesis.Behavioral sciences (Basel, Switzerland) · 2023Review
- Physical activity interventions in older adults with a cognitive impairment: A critical review of reviews.Aging medicine (Milton (N.S.W)) · 2023Review
- Article
- Examining the Interaction between Exercise, Gut Microbiota, and Neurodegeneration: Future Research Directions.Biomedicines · 2023Review
- Usability and Effectiveness of an Individualized, Tablet-Based, Multidomain Exercise Program for People With Dementia Delivered by Nursing Assistants: Protocol for an Evaluation of the InCoPE-App.JMIR research protocols · 2022Article
- Effects of Exercise Training on the Autonomic Nervous System with a Focus on Anti-Inflammatory and Antioxidants Effects.Antioxidants (Basel, Switzerland) · 2022Review
- Personalised treatment for cognitive impairment in dementia: development and validation of an artificial intelligence model.BMC medicine · 2022Article
- ICT-Based Individualized Training of Institutionalized Individuals With Dementia. Evaluation of Usability and Trends Toward the Effectiveness of the InCoPE-App.Frontiers in physiology · 2022Article
- Editorial: ICT-based training intervention for healthy aging: ITIHA.Frontiers in physiology · 2022Article
- Rehabilitation in Dementia.Indian journal of psychological medicine · 2021Article
- Four Weeks of Detraining Induced by COVID-19 Reverse Cardiac Improvements from Eight Weeks of Fitness-Dance Training in Older Adults with Mild Cognitive Impairment.International journal of environmental research and public health · 2021Article
- Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration.International journal of molecular sciences · 2020Review
- Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?Journal of clinical medicine · 2020Review
- The effects of cognitive-motor training interventions on executive functions in older people: a systematic review and meta-analysis.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2020Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence mainly from observational studies supports the notion that lifestyle factors such as regular physical activity can modulate potential risk factors of dementia. Regarding a potential mechanism for this interaction, results from intervention studies show that exercising can induce neuroplastic changes in the human brain. However, a detailed look at the study results reveals a wide interindividual variability in the observed effects. This heterogeneity may originate from the fact that there are "responders" and "non-responders" with respect to the impact of physical exercise on physiological outcome parameters (i.e., VO
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.