Evidence map›Paper›PMID 31244658›Full record

ArticleFrontiers in pharmacology2019

Astrocyte Function Is Affected by Aging and Not Alzheimer's Disease: A Preliminary Investigation in Hippocampi of 3xTg-AD Mice.

Maria Rosanna Bronzuoli, Roberta Facchinetti, Marta Valenza, Tommaso Cassano, Luca Steardo, Caterina Scuderi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
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  6. Aquaporin-4 and Parkinson's Disease.International journal of molecular sciences · 2024
    Review
  7. Review
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  9. Multisensory Stimulation Reverses Memory Impairment in AdrβInternational journal of molecular sciences · 2023
    Article
  10. Role of Senescent Astrocytes in Health and Disease.International journal of molecular sciences · 2023
    Review
  11. Review
  12. Review
  13. Article
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maria Rosanna BronzuoliDepartment of Physiology and Pharmacology "V. Erspamer," Sapienza University of Rome, Rome, Italy.
Roberta FacchinettiDepartment of Physiology and Pharmacology "V. Erspamer," Sapienza University of Rome, Rome, Italy.
Marta ValenzaDepartment of Physiology and Pharmacology "V. Erspamer," Sapienza University of Rome, Rome, Italy.
Tommaso CassanoDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Luca SteardoDepartment of Physiology and Pharmacology "V. Erspamer," Sapienza University of Rome, Rome, Italy.
Caterina ScuderiDepartment of Physiology and Pharmacology "V. Erspamer," Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITUniversity of Foggia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Old age is a risk factor for Alzheimer's disease (AD), which is characterized by hippocampal impairment together with substantial changes in glial cell functions. Are these alterations due to the disease progression or are they a consequence of aging? To start addressing this issue, we studied the expression of specific astrocytic and microglial structural and functional proteins in a validated transgenic model of AD (3×Tg-AD). These mice develop both amyloid plaques and neurofibrillary tangles, and initial signs of the AD-like pathology have been documented as early as three months of age. We compared male 3×Tg-AD mice at 6 and 12 months of age with their wild-type age-matched counterparts. We also investigated neurons by examining the expression of both the microtubule-associated protein 2 (MAP2), a neuronal structural protein, and the brain-derived neurotrophic factor (BDNF). The latter is indeed a crucial indicator for synaptic plasticity and neurogenesis/neurodegeneration. Our results show that astrocytes are more susceptible to aging than microglia, regardless of mouse genotype. Moreover, we discovered significant age-dependent alterations in the expression of proteins responsible for astrocyte-astrocyte and astrocyte-neuron communication, as well as a significant age-dependent decline in BDNF expression. Our data promote further research on the unexplored role of astroglia in both physiological and pathological aging.

Indexed as

3×Tg-AD mouseagingAlzheimer’s diseaseAQP4astrocytebrain-derived neurotrophic factorconnexin-43S100B

Identifiers

PMID31244658
PMCPMC6562169
OpenAlexW2948282677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.