Evidence map›Paper›PMID 31244574›Full record

ReviewAdvanced synthesis & catalysis2019

Stimulus-Responsive Regulation of Enzyme Activity for One-Step and Multi-Step Syntheses.

Christiane Claaßen, Tim Gerlach, Dörte Rother

Abstract readReview
In one paragraph

Review in Advanced synthesis & catalysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
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  5. Review
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  16. Article
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  18. Review
  19. Article
  20. Responsive Emulsions for Sequential Multienzyme Cascades.Angewandte Chemie (International ed. in English) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christiane ClaaßenInstitute of Bio- and Geosciences - Biotechnology (IBG-1) Forschungszentrum Jülich GmbH 52425 Jülich Germany.
Tim GerlachInstitute of Bio- and Geosciences - Biotechnology (IBG-1) Forschungszentrum Jülich GmbH 52425 Jülich Germany.
Dörte RotherInstitute of Bio- and Geosciences - Biotechnology (IBG-1) Forschungszentrum Jülich GmbH 52425 Jülich Germany.

Funding

European Research Council 757320
6 · The paper itself

Abstract

Multi-step biocatalytic reactions have gained increasing importance in recent years because the combination of different enzymes enables the synthesis of a broad variety of industrially relevant products. However, the more enzymes combined, the more crucial it is to avoid cross-reactivity in these cascade reactions and thus achieve high product yields and high purities. The selective control of enzyme activity, i.e., remote on-/off-switching of enzymes, might be a suitable tool to avoid the formation of unwanted by-products in multi-enzyme reactions. This review compiles a range of methods that are known to modulate enzyme activity in a stimulus-responsive manner. It focuses predominantly on

Indexed as

activity regulationbiocatalysisenzyme catalysison-/off-switchingstimuli

Identifiers

PMID31244574
PMCPMC6582597

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.