Evidence map›Paper›PMID 31244520›Full record

ArticleIEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society

Multispectral Endoscopy with Light Gating for Early Cancer Detection.

Le Qiu, Lei Zhang, Vladimir Turzhitsky, Umar Khan, Yuri Zakharov, Kanchan Kantekure, Edward Vitkin, Irving Itzkan, Douglas K Pleskow, Mandeep Sawhney and 3 more

Open access · greenAbstract read
In one paragraph

Article in IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 59 citations in OpenAlex.

  1. Diagnostics (Basel, Switzerland) · 2023
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Le QiuCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215 USA.
Lei ZhangCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215 USA.
Vladimir TurzhitskyCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215 USA.
Umar KhanCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215 USA.
Yuri ZakharovCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215 USA.
Kanchan KantekureCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215 USA; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215 USA.
Edward VitkinCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215 USA.
Irving ItzkanCenter for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215 USA.
Douglas K PleskowCenter for Advanced Endoscopy, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215 USA.
Mandeep SawhneyCenter for Advanced Endoscopy, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215 USA.
Tyler M BerzinCenter for Advanced Endoscopy, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215 USA.
Jeffrey D GoldsmithDepartment of Pathology, Boston Children's Hospital, Harvard University, Boston, MA 02115 USA.
Lev T PerelmanBiological and Biomedical Sciences Program, and also with Center for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02115 USA.
Beth Israel Deaconess Medical Center · USBoston Children's Hospital · US

Funding

In Vivo Optical Detection of Dysplasia in EsophagusR01EB003472 · NIBIB · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PERELMAN, LEV T · 2005 to 2019
$6.1M
Endoscopic Fine-Needle Polarized Scanning Spectroscopy for Pancreatic Cystic Lesions DiagnosisR01EB025173 · NIBIB · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Lev T Perelman · 2017 to 2026
$4.7M
Spectro-Holographic Instrument for Dynamic Sensing of Cancer ProgressionR01CA228029 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PERELMAN, LEV T · 2018 to 2023
$3.4M
Isolation and Assessment of Blood-Circulating Cancer Exosomes with LSS and SERS Lab on a Chip Optical Spectroscopic InstrumentR01CA218382 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PERELMAN, LEV T · 2018 to 2022
$3.3M
(PQ7) In Vivo Cellular Optical Imaging of Esophageal Tumors and MicroenvironmentR01CA205431 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PERELMAN, LEV T · 2016 to 2020
$2.6M
NCI NIH HHS R01 CA205431NCI NIH HHS R01 CA218382NCI NIH HHS R01 CA228029NIBIB NIH HHS R01 EB003472NIBIB NIH HHS R01 EB025173
6 · The paper itself

Abstract

This paper reports the application of endoscopic light scattering spectroscopy (LSS) with light gating to detect malignancies in the biliary and pancreatic ducts, and also reviews the application of endoscopic LSS for differentiating cystic neoplasms in the pancreas and detecting invisible dysplasia in Barrett's esophagus. Information about tissue structure within the superficial epithelium where malignancy starts is present within the spectra of reflected light. Fortunately, this component of the reflected light is not yet randomized. However multiple scattering randomizes the signal from the underlying connective tissue which obscures the desired signal. In order to extract diagnostic information from the reflected signal the multiple scattering component related to connective tissue scattering and absorption must be removed. This is accomplished using described here spatial or polarization gating implemented with endoscopically compatible fiber optic probes.

Indexed as

cancercellular scalelight gatinglight scatteringOptical spectroscopy

Identifiers

PMID31244520
PMCPMC6594557
OpenAlexW2862337338

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.