Evidence map›Paper›PMID 31244519›Full record

ArticleThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry1996

Signaling from Neural Impulses to Genes.

R Douglas Fields

Abstract read
In one paragraph

Article in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Spike frequency decoding and autonomous activation of Ca2+-calmodulin-dependent protein kinase II in dorsal root ganglion neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001
    Article
  5. Developmental expression of the TTX-resistant voltage-gated sodium channels Nav1.8 (SNS) and Nav1.9 (SNS2) in primary sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001
    Article
  6. Gene Chips: Applications to Neuroscience.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2000
    Article
  7. Article
  8. Gene Expression in Hippocampal Long-Term Potentiation.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 1999
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

R Douglas FieldsLaboratory of Developmental Neurobiology, National lnstitutes of Health, NICHD, Bethesda, Maryland.

Funding

Nervous System Development and PlasticityZIAHD000713 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI FIELDS, RICHARD DOUGLAS · 2009 to 2023
$17.7M
Intramural NIH HHS ZIA HD000713
6 · The paper itself

Abstract

Nerve impulses regulate expression of genes that control receptors, channels, enzymes, and structural proteins. This activity-dependent feedback allows adaptation to changing requirements and environmental conditions. The signal transduction mechanisms carrying information from the cell membrane to the nucleus are becoming well characterized, but a more dynamic view of intracellular signaling is emerging to explain cellular responses to specific patterns of neural impulses. This review analyzes this interface between electrophysiology and molecular cell biology to examine the signals, substrates, and processes that enable the nervous system to regulate its structure and function as a consequence of its own operation.

Indexed as

Activity-dependent plasticilyCalcium signalingc-fosCREBDevelopmentGene expressionprotein kinaseSignal transduction

Identifiers

PMID31244519
PMCPMC6594406

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.