Evidence map›Paper›PMID 31244277›Full record

SynthesisAsian Pacific journal of cancer prevention : APJCP2019

Association between IL-18 -607 C/A Polymorphism and the Risk of Prostate Cancer: A Meta-Analysis of Case-Control Studies.

Gao Yuanyuan, Yu Xue, Li Yachao, Feng Xiao, Chen Xu

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Asian Pacific journal of cancer prevention : APJCP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Trial
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  13. Investigating the Relationship ofProstate cancer · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gao YuanyuanDepartment of Clinical Laboratory, First Affiliated Hospital of Soochow University, Suzhou, China. Email: 934944882@qq.com
Yu XueDepartment of Clinical Laboratory, First Affiliated Hospital of Soochow University, Suzhou, China. Email: 934944882@qq.com
Li YachaoCentral Laboratory of Pediatric Research Institute, Affiliated Children's Hospital of Soochow University, Suzhou, China.
Feng XiaoCentral Laboratory of Pediatric Research Institute, Affiliated Children's Hospital of Soochow University, Suzhou, China.
Chen XuDepartment of Clinical Laboratory, First Affiliated Hospital of Soochow University, Suzhou, China. Email: 934944882@qq.com

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Accumulating evidence shows that cytokines play an important role in the proliferation of prostate cancer. This research is trying to determine that IL-18 -607 C/A polymorphism confers susceptibility to prostate cancer. Methods: Meta-analysis was used to collect data. The relevant studies were identified through a comprehensive search from PubMed, Excerpta Medica Database (EMBASE), Web of Science, and Chinese Biomedical Literature Database (CBM) to obtain related studies published up to December 6, 2017. The association between interleukin (IL)-18 -607 C/A polymorphism and prostate cancer risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs). Results: Nine case-control studies from 6 articles were eventually identified. In the overall population, there is a significant association between IL-18 -607 C/A polymorphism and prostate cancer risk in recessive (CC versus CA/AA: OR = 0.20, 95% CI = 0.15-0.27, P = 0.000) or dominant (CC/CA versus AA:OR = 0.42, 95% CI = 0.30–0.57, P = 0.000) models. In the sub-group analysis according to ethnicity, for Asians, IL-18 -607 C/A polymorphism was significantly associated with prostate cancer in allele contrast (C versus. A: OR=0.82, 95%CI=0.70-0.97, P=0.019), homozygote (CC versus. AA: OR=0.68, 95%CI=0.50-0.92, P=0.013), recessive (CC versus. CA/AA: OR=0.19, 95%CI=0.13-0.27, P=0.000), and dominant (CC/CA versus. AA: OR=0.37, 95%CI=0.28-0.48, P=0.000) models, for Caucasians, IL-18 -607 C/A polymorphism was significantly associated with prostate cancer risk in allele contrast (C versus. A: OR=1.27, 95%CI=1.02-1.58, P=0.033), homozygote (CC versus. AA: OR=1.86, 95%CI=1.19-2.91, P=0.007) and recessive (CC versus. CA/AA: OR=0.25, 95%CI=0.19-0.33, P=0.000) models. Conclusion: This meta-analysis has shown that IL-18 -607 C/A polymorphism contributes to a decreased risk of prostate cancer risk in the Asian population but an increased risk in the Caucasian population.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideCase-Control StudiesHumansInterleukin-18MalePrognosisProstatic NeoplasmsIL18 protein, humanInterleukin-18IL-18Meta-analysisPolymorphismProstate Cancer

Identifiers

PMID31244277
PMCPMC7021598

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.