ArticleThe Journal of organic chemistry2019
Regioselective α-Amination of Ethers Using Stable N-Chloroimides and Lithium tert-Butoxide.
Article in The Journal of organic chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Photocatalytic construction ofChemical science · 2026Article
- Unveiling the Significance of tert-Butoxides in Transition Metal-Free Cross-Coupling Reactions.Topics in current chemistry (Cham) · 2024Review
- Photoinduced C(spOrganic letters · 2022Article
- Metal-free visible-light-promoted C(spGreen chemistry : an international journal and green chemistry resource : GC · 2021Article
- Synthesis of Imide and Amine Derivatives via Deoxyamination of Alcohols UsingChemistrySelect · 2021Article
- Photochemical Regioselective C(spOrganic letters · 2021Article
- Amide Synthesis through the In Situ Generation of Chloro- and Imido-Phosphonium Salts.ACS omega · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Herein we describe a metal-free regioselective α-amination of ethers mediated by N-chloroimides in ethereal solvents in the presence of lithium tert-butoxide. This reactivity of N-chloroimides leads to the synthesis of hemiaminal ethers in good to excellent yields at room temperature. This C-H functionalization is achieved without the use of a light, heat source, or external radical initiators. Initial mechanistic work indicates that the reaction proceeds through a radical pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.