ReviewGeroScience2019
Sex differences in health and aging: a dialog between the brain and gonad?
Review in GeroScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Cognitive trajectories and mortality risk in older adults: a 9-year follow-up study.GeroScience · 2026Article
- Genetic regulation of fasting-induced longevity effects.Genetics · 2026Article
- Unveiling the glymphatic system's role in brain aging: A comprehensive biomarker and modifiable intervention target.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sex differences in mitochondrial function in aging mouse skeletal muscle.Frontiers in aging · 2026Article
- Genetic regulation of fasting-induced longevity effects.bioRxiv : the preprint server for biology · 2025Article
- Sex Differences in the Association of Cerebral Blood Flow and Glucose Metabolism in Normative Aging.Human brain mapping · 2025Article
- Review
- Ginkgolide B increases healthspan and lifespan of female mice.Nature aging · 2025Article
- Changes in voxel-wise gray matter asymmetry over time.Frontiers in neuroscience · 2025Article
- Sex, senescence, senolytics, and cognition.Frontiers in aging neuroscience · 2025Review
- Phenome-wide associations of human aging uncover sex-specific dynamics.Nature aging · 2024Article
- Exploring the Influence of Social Class and Sex on Self-Reported Health: Insights from a Representative Population-Based Study.Life (Basel, Switzerland) · 2024Article
- Women, lipids, and atherosclerotic cardiovascular disease: a call to action from the European Atherosclerosis Society.European heart journal · 2023Article
- Considerations for reproducible omics in aging research.Nature aging · 2023Review
- Sex bias in mortality risk changes over the lifespan of bottlenose dolphins.Proceedings. Biological sciences · 2023Article
- Genetic and Epigenetic Sexual Dimorphism of Brain Cells during Aging.Brain sciences · 2023Review
- Age, Education, and Stress Affect Ageing Males' Symptoms More than Lifestyle Does: The Wroclaw Male Study.International journal of environmental research and public health · 2022Article
- Maternal stress programs a demasculinization of glutamatergic transmission in stress-related brain regions of aged rats.GeroScience · 2022Article
- Genetic and social contributions to sex differences in lifespan in Drosophila serrata.Journal of evolutionary biology · 2022Article
- Bridging the Gap: A Geroscience Primer for Neuroscientists With Potential Collaborative Applications.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Women live longer than men in virtually all circumstances. However, a more common pattern among animals is that one sex lives longer under some conditions, the other lives longer under other conditions. In laboratory mice, interventions that extend longevity are surprisingly often sex-specific in their effects. Understanding these conditional sex differences could provide mechanistic insight into how longevity could be modulated in humans. One way that longevity can be consistently enhanced is by inhibiting reproduction or eliminating the capacity to reproduce. Thus, there appears to be a mechanistic link between gonadal activity and longevity. There also appears to be a mechanistic link between some types of neuroendocrine signaling and longevity. Combining these two observations suggest that communication between the brain and gonad is a ripe avenue for further exploring longevity-assurance mechanisms. Also, because the timing and activity of specific brain-gonad endocrine differs between the sexes, neuroendocrine linkages between the brain and gonad, particularly among the less obvious hormones such as activin and inhibin, could provide additional insight into mechanisms of sex differences in aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.