Evidence map›Paper›PMID 31243604›Full record

ArticleNanoscale research letters2019

Potent anti-tumor immunostimulatory biocompatible nanohydrogel made from DNA.

Jiana Jiang, Xianming Kong, Yuexia Xie, Hanbing Zou, Qianyun Tang, Ding Ma, Xue Zhao, Xiaozhen He, Anyue Xia, Peifeng Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale research letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiana JiangCentral Laboratory, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, People's Republic of China.
Xianming KongCentral Laboratory, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, People's Republic of China.
Yuexia XieCentral Laboratory, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, People's Republic of China.
Hanbing ZouCentral Laboratory, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, People's Republic of China.
Qianyun TangState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, People's Republic of China.
Ding MaCentral Laboratory, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, People's Republic of China.
Xue ZhaoCentral Laboratory, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, People's Republic of China.
Xiaozhen HeCentral Laboratory, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, People's Republic of China.
Anyue XiaCentral Laboratory, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, People's Republic of China.
Peifeng LiuCentral Laboratory, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, People's Republic of China. lpf@sjtu.edu.cn.

Funding

National Natural Science Foundation of China 81472842National Natural Science Foundation of China 81560495National Natural Science Foundation of China 81771968National Natural Science Foundation of China 81773222Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant 20181705Shanghai Talent Development Fund 2017053
6 · The paper itself

Abstract

Unmethylated CpG oligodeoxynucleotides are potent immunostimulatory motifs in activating both innate and acquired immune system by inducing Th1 type antigen-specific T cell responses, but their instability in serum greatly influences their immunostimulant efficiency. Here, we constructed a novel immuno-DNA nanohydrogels consisting of tandem repeat sequences of CpG units named CpG-MCA nanohydrogels through multi-primed chain amplification. CpG-MCA nanohydrogels were proved to resist degradation and increase the proliferation and migration of murine macrophage-like RAW264.7 cells. Furthermore, CpG-MCA nanohydrogels effectively induced high expression of tumor necrosis factor-α and interleukin-6, and remarkably inhibited the proliferation of U251 cells, suggesting that CpG-MCA nanohydrogels are expected to be employed as the potent anti-cancer immunostimulant.

Indexed as

CpGGliomaImmunotherapyMacrophageNanohydrogel

Identifiers

PMID31243604
PMCPMC6595017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.